Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review
Porta-Sánchez A, Gilbert C, Thavendiranathan P et al.
ECG ; QT interval electrocardiography; cancer therapy; cardiac arrhythmia; cardio‐oncology; oncology; sudden death; torsade de pointes; tyrosine kinase inhibitors
BACKGROUND - The cardiovascular complications of cancer therapeutics are the focus of the burgeoning field of cardio-oncology. A common challenge in this field is the impact of cancer drugs on cardiac repolarization (ie, QT prolongation) and the potential risk for the life-threatening arrhythmia torsades de pointes. Although QT prolongation is not a perfect marker of arrhythmia risk, this has become a primary safety metric among oncologists. Cardiologists caring for patients receiving cancer treatment should become familiar with the drugs associated with QT prolongation, its incidence, and appropriate management strategies to provide meaningful consultation in this complex clinical scenario.
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