Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI
Götberg M, Christiansen EH, iFR-SWEDEHEART Investigators et al.
KEYWORDS
iFR; FFR; stable angina; ACS; coronary-artery stenosis; non inferiority; MACE
BACKGROUND - The instantaneous wave-free ratio (iFR) is an index used to assess the severity of coronary-artery stenosis. The index has been tested against fractional flow reserve (FFR) in small trials, and the two measures have been found to have similar diagnostic accuracy. However, studies of clinical outcomes associated with the use of iFR are lacking. We aimed to evaluate whether iFR is noninferior to FFR with respect to the rate of subsequent major adverse cardiac events.