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腔内影像学与负性重构

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2014年PROSPECT研究“Impact of Positive and Negative Lesion Site Remodeling on Clinical Outcomes : Insights From PROSPECT”数据显示ACS患者非罪犯病变中正性、负性重构病变处MACE发生机率更高，负性重构病变处的最小管腔面积最小，经IVUS明确的薄纤维帽(IVUS-virtual histology thin-cap fibroatheroma ,VH TCFA)最常见在负性重构病变处；而正性重构病变处的斑块负荷最重。


2015年“A Combined Optical Coherence Tomography and Intravascular Ultrasound Study on Plaque Rupture, Plaque Erosion, and Calcified Nodule in Patients With ST-Segment Elevation Myocardial Infarction: Incidence, Morphologic Characteristics, and Outcomes After Percutaneous Coronary Intervention”介绍了PCI-STEMI患者经OCT判定的斑块破裂（plaque rupture, PR），斑块浸润(plaque erosion, PE), 和钙化结节(calcified nodule, CN) 的发生率、形态特征和PCI预后。


2018年“Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study”阐述了II型糖尿病患者经IVUS观察到的冠脉负性重构与血清中糖化白蛋白（glycated albumin, GA ）水平升高及糖基化终末产物受体（endogenous secretory receptor for advanced glycation end products, esRAGE）浓度降低相关，然而II型糖尿病患者频现冠脉负性重构的机制尚不清楚。


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