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Review Article2018 Nov 29.

JOURNAL：Catheter Cardiovasc Interv. Article Link

Outcomes with drug-coated balloons in small-vessel coronary artery disease

Megaly M, Rofael M, Saad M et al. Keywords: drug-coated balloons; drug-eluting balloons; small-vessel disease coronary disease

ABSTRACT

BACKGROUND - Percutaneous coronary intervention (PCI) of small-vessel coronary artery disease (SVD) is associated with increased risk of restenosis. The use of drug-coated balloons (DCBs) in SVD has received limited study.


OBJECTIVES - To assess the outcomes of DCB in the treatment of SVD compared with the standard of care.


METHODS - We performed a meta-analysis of all studies published between January 2000 and September 2018 reporting the outcomes of DCB versus other modalities in the treatment of de novo SVD.


RESULTS - Seven studies with 1,824 patients (1,938 lesions) were included (four randomized controlled trials and three observational studies). During a mean follow-up of 14.5 ± 10 months, DCBs were associated with a similar risk of target lesion revascularization (TLR) (OR: 0.99, 95% CI: 0.54, 1.84, P = 0.97) and major adverse cardiovascular events (MACE) (OR: 0.86, 95% CI: 0.51, 1.45, P = 0.57) compared with drug-eluting stents (DES). During a mean follow-up of 7 ± 1.5 months, DCBs were associated with a significantly lower risk of TLR (OR: 0.19, 95% CI 0.04-0.88, P = 0.03) and binary restenosis (OR: 0.17, 95% CI 0.08-0.37, P = <0.00001) compared with noncoated balloon angioplasty.


CONCLUSION - The use of DCBs in SVD is associated with comparable outcomes when compared with DES and favorable outcomes when compared with balloon angioplasty.

© 2018 Wiley Periodicals, Inc.

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