Review ArticleVolume 76, Issue 6, August 2020
JOURNAL:J Am Coll Cardiol. Article Link
Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel
JE Wilcox, JC Fang, KB Margulies et al.
Keywords:
heart failure with recovered ejection fraction; myocardial recovery
ABSTRACT
Reverse left ventricular (LV) remodeling and recovery of LV function are
associated with improved clinical outcomes in patients with heart
failure with reduced ejection fraction. A growing body of evidence
suggests that even among patients who experience a complete
normalization of LV ejection fraction, a significant proportion will
develop recurrent LV dysfunction accompanied by recurrent heart failure
events. This has led to intense interest in understanding how to manage
patients with heart failure with recovered ejection fraction (HFrecEF).
Because of the lack of a standard definition for HFrecEF, and the
paucity of clinical data with respect to the natural history of HFrecEF
patients, there are no current guidelines on how these patients should
be followed up and managed. Accordingly, thisJACCScientific
Expert Panel reviews the biology of reverse LV remodeling and the
clinical course of patients with HFrecEF, as well as provides guidelines
for defining, diagnosing, and managing patients with HFrecEF.