Atherosclerosis is an inflammatory disease. Because high plasma 
concentrations of cholesterol, in particular those of low-density 
lipoprotein (LDL) cholesterol, are one of the principal risk factors for
 atherosclerosis,1 the process of atherogenesis has been 
considered by many to consist largely of the accumulation of lipids 
within the artery wall; however, it is much more than that. Despite 
changes in lifestyle and the use of new pharmacologic approaches to 
lower plasma cholesterol concentrations,2,3 cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.4,5 In fact, the lesions of atherosclerosis represent . . .