Cardiovascular disease (CVD) remains the leading cause of morbidity and 
mortality for women in the United States and worldwide. There has been 
no American College of Cardiology (ACC)/American Heart Association 
guideline update specifically for the prevention of CVD in women since 
2011. Since then, the body of sex-specific data has grown, in addition 
to updated hypertension, cholesterol, diabetes, atrial fibrillation, and
 primary prevention guidelines. The ACC CVD in Women Committee undertook
 a review of the recent guidelines and major studies to summarize 
recommendations pertinent to women. In this update, the authors address 
special topics, particularly the risk factors and treatments that have 
led to some controversies and confusion. Specifically, sex-related risk 
factors, hypertension, diabetes, hyperlipidemia, anticoagulation for 
atrial fibrillation, use of aspirin, perimenopausal hormone therapy, and
 psychosocial issues are highlighted.