科学研究 - The Left Main and Coronary Artery Bifurcation Lesion Summit (CBS)

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients

Original Research | By Reardon MJ, Van Mieghem NM, SURTAVI Investigators.

BACKGROUND - Although transcatheter aortic-valve replacement (TAVR) is an accepted alternative to surgery in patients with severe aortic stenosis who are at high surgical risk, less is known about comparative outcomes among patients with aortic stenosis who are at intermediate surgical risk. METHODS - We evaluated the clinical outcomes in intermediate-risk patients with severe, symptomatic aortic ste...

Prevalence of anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease: data from the International Observational CLARIFY Registry

Original Research | By Steg PG, Greenlaw N, Prospective Observational Longitudinal Registry of Patients With Stable Coronary Artery Disease (CLARIFY) Investigators.

IMPORTANCE - In the era of widespread revascularization and effective antianginals, the prevalence and prognostic effect of anginal symptoms and myocardial ischemia among patients with stable coronary artery disease (CAD) are unknown. OBJECTIVE - To describe the current clinical patterns among patients with stable CAD and the association of anginal symptoms or myocardial ischemia with clinical outco...

Temporal Trends in Transcatheter Aortic Valve Replacement in France: FRANCE 2 to FRANCE TAVI

Original Research | By Auffret V, Lefevre T, FRANCE TAVI Investigators.

Original Research | By J Tromp, L Shen, PS Jhund et al.

BACKGROUND- Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. OBJECTIVES- This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. METHODS- Using data on patients with left ventricular ejection fractio...

Left Main Stenting: What We Have Learnt So Far?

Editorial | By D Dash, SL Chen, JJ Zhang.

Differences between the left main and other bifurcations

Expert Opinion | By Lefèvre T, Girasis C, Lassen JF.

The left main is the largest bifurcation of the coronary tree and is, therefore, easier to access. Nevertheless, the risks of untoward consequences associated with the loss of the side branch are much higher. Although the usual technical strategies implemented in coronary bifurcations can generally be applied to left main lesions, several inherent characteristics (the ostial position of the main branch, the size of the side branch, the amount of cal...

The Evolution of β-Blockers in Coronary Artery Disease and Heart Failure (Part 1/5)

Review Article | By P Joseph, K Swedberg, DP Leong et al.

As new treatments continue to improve clinical outcomes in coronary artery disease (CAD) and heart failure, it is necessary to characterize the appropriate use of β-adrenergic receptor blockers (β-blockers) in the contemporary management of these conditions. This review examines the current evidence supporting β-blocker use in heart failure with preserved ejection fraction (HFpEF), heart failure with midrange ejection fraction (HFmEF),...

From ACE Inhibitors/ARBs to ARNIs in Coronary Artery Disease and Heart Failure (Part 2/5)

Review Article | By DP Leong, JJV McMurray, PG Joseph et al.

The pharmacological inhibition of the renin-angiotensin-aldosterone system as a therapeutic strategy is one of the most significant advances in the treatment and prevention of cardiovascular disease in heart failure with reduced ejection fraction and in coronary artery disease. Recently, the addition of neprilysin inhibition to angiotensin receptor blockade has been shown to be even more effective than angiotensin-converting enzyme inh...

Antithrombotics From Aspirin to DOACs in Coronary Artery Disease and Atrial Fibrillation (Part 3/5)

Review Article | By FWA Verheugt, JM ten Berg, RF Storey et al.

For secondary prevention of coronary artery disease (CAD), oral antiplatelet therapy is essential. In case of coronary intervention, temporary dual antiplatelet therapy is mandatory as well. Recently, low-dose oral anticoagulation has entered the CAD arena. Atrial fibrillation (AF) is often seen in CAD and vice versa. In most patients stroke prevention in AF consists of oral anticoagulation. In many cases of CAD in patients with AF, ...

Atherosclerosis — An Inflammatory Disease

Review Article | By Ross R

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the principal risk factors for atherosclerosis,1 the process of atherogenesis has been considered by many to consist largely of the accumulation of lipids within the artery wall; however, it is much more than that. Despite changes in lifestyle and the use of new pharmacolog...