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Targeting the Immune System in Atherosclerosis: JACC State-of-the-Art Review

Review Article | By TX Zhao, Z Mallat.

Atherosclerosis has long been known as an inflammatory disease. However, whether targeting inflammation improves outcomes was unproven until the recent results of CANTOS (Canakinumab Anti-InflammatoryThrombosis Outcomes Study). In this review, we reflect on why it has taken a long time to prove the inflammatory hypothesis of atherosclerosis and derive important lessons for the future. In particular, we discuss the...

Cardiovascular Aging and Heart Failure: JACC Review Topic of the Week

Review Article | By F Triposkiadis, A Xanthopoulos, J Butler et al.

Heart failure (HF) is a clinical syndrome that usually develops in the elderly. Complex interactions of the cardiovascular aging process with risk factors (obesity, hypertension, and atherosclerosis), comorbidities (anemia, chronic kidney disease, diabetes, and so on), and disease modifiers (sex, genes, others) contribute to the development of HF phenotype and outcome. A conglomerate of cellular and molecular mechanisms underl...

Galectin-3 Levels and Outcomes After Myocardial Infarction: A Population-Based Study

Original Research | By R Asleh, M Enriquez-Sarano, AS Jaffe et al.

  BACKGROUND -  Galectin-3 (Gal-3) is implicated in cardiac fibrosis, but its association with adverse outcomes after myocardial infarction (MI) is unknown.   OBJECTIVES -  The purpose of this study was to examine the prognostic value of Gal-3 in a community cohort of incident MI.   METHODS -  A population-based incidence MI cohort was pros...

Mechanisms of Vascular Aging, A Geroscience Perspective JACC Focus Seminar

Review Article | By Z Ungvari, S Tarantini, F Sorond et al.

Age-related pathological alterations of the vasculature have a critical role in morbidity and mortality of older adults. In epidemiological studies, age is the single most important cardiovascular risk factor that dwarfs the impact of traditional risk factors. To develop novel therapeutic interventions for prevention of age-related vascular pathologies, it is crucial to understand the cellular and molecular mechanisms of vascular aging. In this revi...

Biological Versus Chronological Aging: JACC Focus Seminar

Review Article | By MR Hamczyk, RM Nevado, A Barettino et al.

Treatment of higher-risk patients with an indication for revascularization: evolution within the field of contemporary percutaneous coronary intervention

Review Article | By AJ Kirtane, D Doshi, MB Leon et al.

Cardiovascular Mortality After Type 1 and Type 2 Myocardial Infarction in Young Adults

Original Research | By A Singh, DL Bhatt, R Blankstein et al.

BACKGROUND - Type 2 myocardial infarction (MI) and myocardial injury are associated with increased short-term mortality. However, data regarding long-term mortality are lacking.   OBJECTIVES  - This study compared long-term mortality among young adults with type 1 MI, type 2 MI, or myocardial injury.   METHODS  - Adults age 50 years or younger who pres...

Drug-Coated Balloon for De Novo Coronary Artery Disease: JACC State-of-the-Art Review

Review Article | By C Yerasi, BC Case, BJ Forrestal et al.

Percutaneous coronary intervention with a drug-eluting stent is the most common mode of revascularization for coronary artery disease. However, restenosis rates remain high. Non-stent-based local drug delivery by a drug-coated balloon (DCB) has been investigated, as it leaves no metallic mesh. A DCB consists of a semicompliant balloon coated with antiproliferative agents encapsulated in a polymer matrix, which is release...

Survival After Coronary Revascularization With Paclitaxel-Coated Balloons

Review Article | By B Scheller, D Vukadinovic, R Jeger et al.

BACKGROUND - Drug-coated balloons (DCBs) are accepted treatment strategies for coronary in-stent restenosis and are under clinical investigation for lesions without prior stent implantation. A recently published meta-analysis suggested an increased risk of death associated with the use of paclitaxel-coated devices in the superficial femoral artery. The reasons are incompletely understood as potential underlying pathomechanisms remai...

Combined Tricuspid and Mitral Versus Isolated Mitral Valve Repair for Severe MR and TR: An Analysis From the TriValve and TRAMI Registries

Original Research | By M Mehr, J Hausleiter and for the TriValve and TRAMI Investigators.

OBJECTIVES - The aim of this study was to retrospectively compare the characteristics, procedural courses, and outcomes of patients presenting with concomitant mitral regurgitation (MR) and tricuspid regurgitation (TR) in the TriValve (Transcatheter Tricuspid Valve Therapies) and TRAMI (Transcatheter Mitral Valve Interventions) registries.   BACKGROUND -  Transcatheter mitral edge-to...

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