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2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients

Clinical Trial | By JK Forrest, GM Deeb, SJ Yakubov et al.

BACKGROUND - The Evolut Low Risk Trial (Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients) showed that transcatheter aortic valve replacement (TAVR) with a supra-annular, self-expanding valve was noninferior to surgery for the primary endpoint of all-cause mortality or disabling stroke at 2 years. This finding was based on a Bayesian analysis performed after 850 patients had reach...

5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve

Clinical Trial | By M Götberg, K Berntorp, R Rylance et al.

BACKGROUND - Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking. OBJECTIVES - The purpose of this study was to investigate the prespecified 5-year follow-up of...

Propensity-Matched 1-Year Outcomes Following Transcatheter Aortic Valve Replacement in Low-Risk Bicuspid and Tricuspid Patients

Original Research | By GM Deeb, MJ Reardon, B Ramlawi et al.

OBJECTIVES - The aim of this study was to compare 1-year outcomes after transcatheter aortic valve replacement (TAVR) in low surgical risk patients with bicuspid aortic stenosis to patients with tricuspid aortic stenosis.   BACKGROUND - The pivotal TAVR trials excluded patients with bicuspid aortic valves. The Low Risk Bicuspid Study 30-day primary endpoint of death or disabling stroke was 1.3%. ...

Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

Original Research | By X Zhang, XL Zhang, YL Han et al.

Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis

Review Article | By W Masson, A Lavalle-Cobo, JP Nogueira et al.

Impact of epicardial adipose tissue on cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure

Original Research | By NR Pugliese, F Paneni, M Mazzola et al.

AIMS - We evaluated the impact of echocardiographic epicardial adipose tissue (EAT) on cardiovascular haemodynamics, metabolic profile and prognosis in heart failure (HF) using combined cardiopulmonary-echocardiography exercise stress.   METHODS AND RESULTS - We analysed EAT thickness of HF patients with reduced (HFrEF, n = 205) and preserved (HFpEF, n = 188) ejection fraction, including 44 contro...

Active factor XI is associated with the risk of cardiovascular events in stable coronary artery disease patients

Original Research | By E Paszeka, E Pociask, A Undas et al.

BACKGROUND AND AIMS - Tissue factor (TF) and activated factor XI (FXIa) have been associated with acute coronary syndrome, ischemic stroke and venous thromboembolism. Their predictive value in stable coronary artery disease (CAD) is unclear. We investigated whether active TF and FXIa were associated with clinical outcomes in CAD patients in long-term observation. METHODS - In 124 stable patients with mul...

Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses

Original Research | By D Ibi, M Boot, MET Dollé et al.

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Guideline | By Writing Committee Members, PA Heidenreich, B Bozkurt et al.

Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry

Original Research | By M Simonato, S Vemulapalli, OB-Yehuda et al.

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2022 Mar, 15 (5) 511–522 1

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