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Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

Clinical Trial | By Cannon CP, Bhatt DL, Oldgren J et al.

Background - Triple antithrombotic therapy with warfarin plus two antiplatelet agents is the standard of care after percutaneous coronary intervention (PCI) for patients with atrial fibrillation, but this therapy is associated with a high risk of bleeding. Methods - In this multicenter trial, we randomly assigned 2725 patients with atrial fibrillation who had undergone PCI to triple therapy with warfarin plus a P2Y12 inhibito...

Oxygen Therapy in Suspected Acute Myocardial Infarction

Clinical Trial | By Hofmann R, James SK, Jernberg T et al.

Background - The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. Methods - In this registry-based randomized clinical trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients with suspected myocardial infarction and an oxygen saturation of 90% or higher were random...

Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study

Clinical Trial | By Cuisset T, Deharo P, Quilici J et al.

AIMS - Newer P2Y12 blockers (prasugrel and ticagrelor) demonstrated significant ischaemic benefit over clopidogrel after acute coronary syndrome (ACS). However, both drugs are associated with an increase in bleeding complications. The objective of the present study was to evaluate the benefit of switching dual antiplatelet therapy (DAPT) from aspirin plus a newer P2Y12 blocker to aspirin plus clopidogrel 1 month, were as...

Usefulness of the SYNTAX score II to validate 2-year outcomes in patients with complex coronary artery disease undergoing percutaneous coronary intervention: A large single-center study

Clinical Trial | By Song Y, Gao Z, Tang X et al.

Background - 20 (n 1474); SS-II 20-26 (n 1462); and SS-II > =1462). The predictive ability for 2-year mortality was compared between angiographic scores and scores combining both angiographic and clinical variables. < = 0.740 vs baseline SS 0.620; P As a risk score combining both anatomical and clinical variables, SS-II demonstrated superiority compared with the purely angio...

Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial

Clinical Trial | By Sibbing D, Aradi D, Jacobshagen C et al.

Background - Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous coronary intervention (PCI). However, the greatest anti-ischaemic benefit of potent antiplatelet drugs over the less potent clopidogrel occurs early, while most excess bleeding events arise during chronic treatment. Hence, a stage-adapted treatment with potent platelet inhibition...

In Vivo Calcium Detection by Comparing Optical Coherence Tomography, Intravascular Ultrasound, and Angiography

Clinical Trial | By Wang X, Matsumura M, Mintz GS et al.

OBJECTIVES- The aim of this study was to evaluate optical coherence tomography (OCT) and intravascular ultrasound (IVUS) versus coronary angiography in the assessment of target lesion calcification and its effect on stent expansion. BACKGROUD - IVUS is more sensitive than angiography in the detection of coronary artery calcium, but the relationship among IVUS, OCT, and angiograp...

Meta-Analysis of Comparison of 5-Year Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Unprotected Left Main Coronary Artery in the Era of Drug-eluting Stents

Review Article | By Khan MR, Kayani WT, Alam M et al.

Patients with unprotected left main coronary artery (ULMCA) disease are increasingly being treated with percutaneous coronary intervention (PCI) using drug-eluting stents (DES), but long-term outcomes comparing PCI with coronary artery bypass grafting (CABG) remain limited. We performed aggregate data meta-analyses of clinical outcomes (all-cause death, nonfatal myocardial infarction, stroke, repeat revascularization, cardiac death, and majo...

2017 AHA/ACC Clinical Performance and Quality Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures

Guideline | By Jneid H, Addison D, Bhatt DL et al.

Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis

Review Article | By Giacoppo D, Colleran R, Cassese S et al.

IMPORTANCE -  In patients with left main coronary artery (LMCA) stenosis, coronary artery bypass grafting (CABG) has been the standard therapy for several decades. However, some studies suggest that percutaneous coronary intervention (PCI) with drug-eluting stents may be an acceptable alternative. OBJECTIVE - To compare the long-term safety of PCI with drug-eluting stent vs C...

Risk of Early Adverse Events After Clopidogrel Discontinuation in Patients Undergoing Short-Term Dual Antiplatelet Therapy: An Individual Participant Data Analysis

Clinical Trial | By Piccolo R, Feres F, Valgimigli M et al.

OBJECTIVES - The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials. BACKGROUND - It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events. METHODS - The authors performed an individual participant data analysis and aggr...

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Original Research 785
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N Engl J Med. 1
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JACC Cardiovasc Imaging. 1
Eur Heart J. 1
Circ Cardiovasc Qual Outcomes. 1
Catheter Cardiovasc Interv. 1
Am J Cardiol. 1

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