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The Astronaut Cardiovascular Health and Risk Modification (Astro-CHARM) Coronary Calcium Atherosclerotic Cardiovascular Disease Risk Calculator

Original Research | By A Khera , MJ Budoff , CJ O’Donnell et al.

BACKGROUND - Coronary artery calcium (CAC) is a powerful novel risk indicator for atherosclerotic cardiovascular disease (ASCVD). Currently, there is no available ASCVD risk prediction tool that integrates traditional risk factors and CAC. METHODS - To develop a CAC ASCVD risk tool for younger individuals in the general population, subjects aged 40-65 without prior CVD from three population-based...

10-Year Coronary Heart Disease Risk Prediction Using Coronary Artery Calcium and Traditional Risk Factors: Derivation in the MESA (Multi-Ethnic Study of Atherosclerosis) With Validation in the HNR (Heinz Nixdorf Recall) Study and the DHS (Dallas Heart Study)

Clinical Trial | By McClelland RL, Jorgensen NW, Budoff M et al.

BACKGROUND - Several studies have demonstrated the tremendous potential of using coronary artery calcium (CAC) in addition to traditional risk factors for coronary heart disease (CHD) risk prediction. However, to date, no risk score incorporating CAC has been developed. OBJECTIVES - The goal of this study was to derive and validate a novel risk score to estimate 10-year CHD risk using CAC and traditio...

Prognostic Implication of Thermodilution Coronary Flow Reserve in Patients Undergoing Fractional Flow Reserve Measurement

Original Research | By JM Lee, KH Choi, D Hwang et al.

OBJECTIVES - This study investigated the prognostic implication of coronary flow reserve (CFR) in patients who underwent fractional flow reserve (FFR) measurement. BACKGROUND - Limited data are available regarding the long-term prognosis associated with thermodilution CFR in patients with coronary artery disease. METHODS - A total of 519 patients (737 vessels) who did not undergo re...

Screening for Atrial Fibrillation With Electrocardiography US Preventive Services Task Force Recommendation Statement

| By US Preventive Services Task Force

Screening for Atrial Fibrillation With ECG: USPSTF Recommendation

Expert Opinion | By Eugene H. Chung, MD, FACC

A Randomized Study of Distal Filter Protection Versus Conventional Treatment During Percutaneous Coronary Intervention in Patients With Attenuated Plaque Identified by Intravascular Ultrasound

Clinical Trial | By K Hibi, K Kozuma, S Sonoda et al.

OBJECTIVES - The aim of this study was to evaluate the utility of distal protection during percutaneous coronary intervention (PCI) in patients with acute coronary syndromes at high risk for distal embolization. BACKGROUND - The results of previous clinical trials indicated that the routine use of distal protection in patients with ST-segment elevation myocardial infarction did not improve clinical outcomes. Howe...

Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes

Original Research | By Javier Escaned, Nicola Ryan, Hernán Mejía-Rentería

OBJECTIVES - The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS). BACKGROUND - Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the ...

New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy

Original Research | By D Nakamura, W Wijns, MJ Price et al.

OBJECTIVES - This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). BACKGROUND - The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis o...

Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction

Original Research | By Y Wang, J Li, LX Jiang et al.

IMPORTANCE - Patients who survive acute myocardial infarction (AMI) have a high risk of subsequent major cardiovascular events. Efforts to identify risk factors for recurrence have primarily focused on the period immediately following AMI admission. OBJECTIVES - To identify risk factors and develop and evaluate a risk model that predicts 1-year cardiovascular events after AMI. DESIGN, SETTI...

Deficiency of GATA3-Positive Macrophages Improves Cardiac Function Following Myocardial Infarction or Pressure Overload Hypertrophy

Original Research | By MJ Yang, L Song, L Wang et al.

BACKGROUND - Macrophages are highly plastic cells that play an important role in the pathogenesis of cardiovascular disease. OBJECTIVES - This study investigated the role of GATA3-positive macrophages in modulating cardiac function after myocardial infarction (MI) or in response to pressure overload hypertrophy. METHODS - Myeloid-specific GAT...

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