科学研究 - The Left Main and Coronary Artery Bifurcation Lesion Summit (CBS)

In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions

Original Research | By Adjedj J, Picard F, Mogi S et al.

OBJECTIVES - To evaluate, in vitro, SB stenting techniques after failed provisional stenting. We aimed to compare flows and stent strut apposition of T and protrusion (TAP) versus Reversed String (RS) techniques using a flow simulator, optical coherence tomography (OCT) using silicon bifurcation phantoms with different bifurcation angulations. BACKGROUND - While bifurcation coronary artery steno...

Self-expandable sirolimus-eluting stents compared to second-generation drug-eluting stents for the treatment of the left main: A propensity score analysis from the SPARTA and the FAILS-2 registries

Original Research | By Montefusco A, D'Ascenzo F, Gili S et al.

OBJECTIVES - To compare the effectiveness and safety of self-expandable, sirolimus-eluting Stentys stents (SES) and second-generation drug-eluting stents (DES-II) for the treatment of the unprotected left main (ULM). BACKGROUND - SES may provide a valuable option to treat distal ULM, particularly when significant caliber gaps with side branches are observed. METHODS - Patients from t...

Randomized study of doxorubicin-based chemotherapy regimens, with and without sildenafil, with analysis of intermediate cardiac markers

Clinical Trial | By Poklepovic A, Qu Y, Dickinson M et al.

Cardiorespiratory Fitness and Mortality in Healthy Men and Women

Original Research | By MT Imboden, MP Harber, MH Whaley et al.

BACKGROUND - There is a well-established inverse relationship between cardiorespiratory fitness (CRF) and mortality. However, this relationship has almost exclusively been studied using estimated CRF. OBJECTIVES - This study aimed to assess the association of directly measured CRF, obtained using cardiopulmonary exercise (CPX) testing with all-cause, cardiovascular disease (CVD), and cancer mortal...

Lifestyle Modifications for Preventing and Treating Heart Failure

Original Research | By M Aggarwal, B Bozkurt, on behalf of American College of Cardiology’s Nutrition and Lifestyle Committee of the Prevention of Cardiovascular Disease Council.

A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation

Clinical Trial | By Abraham WT, Kuck KH, FIX-HF-5 Investigators and Coordinators.

OBJECTIVES - This study sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUN...

A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and baseline patient characteristics.

Clinical Trial | By Abraham WT, , FIX-HF-5 Investigators and Coordinators.

Cardiac contractility modulation (CCM) signals are nonexcitatory electrical signals delivered during the cardiac absolute refractory period that enhance the strength of cardiac muscular contraction. Prior research in experimental and human heart failure has shown that CCM signals normalize phosphorylation of key proteins and expression of genes coding for proteins involved in regulation of calcium cycling and contraction. The results of prior c...

sST2 Predicts Outcome in Chronic Heart Failure Beyond NT−proBNP and High-Sensitivity Troponin T

Original Research | By M Emdin, A Aimo, G Vergaro et al.

BACKGROUND - Soluble suppression of tumorigenesis-2 (sST2) is a biomarker related to inflammation and fibrosis. OBJECTIVES - This study assessed the independent prognostic value of sST2 in chronic heart failure (HF). METHODS - Individual patient data from studies that assessed sST2 for risk prediction in chronic HF, together with N-terminal pro−B-type natriure...

Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study

Clinical Trial | By Sparks JA, Barbhaiya M, Karlson EW et al.

Ejection Fraction Pros and Cons: JACC State-of-the-Art Review

Review Article | By TH Marwick

Ejection fraction (EF) reflects both cardiac function and remodeling, and is widely recognized as a valuable diagnostic and prognostic tool. Its use in a variety of settings, ranging from heart failure and myocardial infarction to valvular heart disease, has made it a cornerstone of modern cardiology, pervading guidelines and practice. However, the development of the test was in another era, with younger patients and a lo...