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Randomized Trial Evaluating Percutaneous Coronary Intervention for the Treatment of Chronic Total Occlusion: The DECISION-CTO Trial

Clinical Trial | By Lee SW, Lee PH, Park SJ et al.

BACKGROUND - Procedural results for percutaneous coronary intervention (PCI) in coronary vessels with chronic total occlusion (CTO) have improved in recent years, and PCI strategies have moved toward more complete revascularization with more liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies and small clinical trials. METHODS - In this open-label...

Association of Cardiovascular Disease With Respiratory Disease

Original Research | By P Carter, J Lagan, C Fortune et al.

BACKGROUND- The relationship between respiratory diseases and individual cardiovascular diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory disease, are unclear.   OBJECTIVES- This study sought to determine the relationship between chronic obstructive pulmonary disease (COPD), asthma and interstitial lung disease (ILD), and individual cardiovascular diseases, and evalu...

Association Between Functional Impairment and Medication Burden in Adults with Heart Failure

Original Research | By Goyal P, Bryan J, Kneifati-Hayek J et al.

OBJECTIVES - To determine whether the number of medications taken by adults with heart failure (HF) and impairment in activities of daily living (ADL)-a subpopulation in whom the risks of a high medication burden may outweigh the benefits-differs from the number taken by those without impairment in ADLs. DESIGN -  Cross-sectional. SETTING -  National Health...

Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines

Original Research | By Bevan GH, Kalra A, Josephson RA, Al-Kindi SG

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing JACC Scientific Expert Panel

Expert Opinion | By Januzzi JL Jr, Mahler SA, Christenson RH et al.

High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding greater clinical sensitivity for myocardial injury and allowin...

Management of No-Reflow Phenomenon in the Catheterization Laboratory

Review Article | By Rezkalla SH, Stankowski RV, Hanna J et al.

Advances in Coronary No-Reflow Phenomenon-a Contemporary Review

Review Article | By Karimianpour A, Maran A.

PURPOSE OF REVIEW - Coronary artery no-reflow phenomenon is an incidental outcome of percutaneous coronary intervention in patients presenting with acute myocardial infarction. Despite advances in pharmacologic and non-pharmacologic therapies, coronary no-reflow phenomenon occurs more commonly than desired. It often results in poor clinical outcomes and remains as a relevant consideration in the cardiac catheterization laborator...

Society of cardiac angiography and interventions: suggested management of the no-reflow phenomenon in the cardiac catheterization laboratory

Review Article | By Klein LW, Kern MJ, Interventional Cardiology Committee of the Society of Cardiac Angiography and Interventions.

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Management of two major complications in the cardiac catheterisation laboratory: the no-reflow phenomenon and coronary perforations

Original Research | By Muller O, Windecker S, Cuisset T et al.

The no-reflow phenomenon has been defined in 2001 by Eeckhout and Kern as inadequate myocardial perfusion through a given segment of the coronary circulation without angiographic evidence of mechanical vessel obstruction1. Rates of cardiac death and non-fatal cardiac events are increased in patients with compared to those without no-reflow2,3. The term “no reflow” encompasses the slow-flow, slow-reflow, no-flow and low-fl...

An open-Label, 2 × 2 factorial, randomized controlled trial to evaluate the safety of apixaban vs. vitamin K antagonist and aspirin vs. placebo in patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention: Rationale and design of the AUGUSTUS trial

Clinical Trial | By Lopes RD, Vora AN, Liaw D et al.

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