科学研究 - The Left Main and Coronary Artery Bifurcation Lesion Summit (CBS)

In-Hospital Outcomes of Chronic Total Occlusion Percutaneous Coronary Interventions in Patients With Prior Coronary Artery Bypass Graft Surgery

Original Research | By Tajti P, Karmpaliotis D, Alaswad K et al.

BACKGROUND - We examined the procedural outcomes of chronic total occlusions (CTO) percutaneous coronary interventions in patients with prior coronary artery bypass graft surgery (CABG). METHODS AND RESULTS - We compared the clinical, angiographic characteristics and outcomes of 3486 CTO interventions performed in patients with (n=1101) and without (n=2317) prior CABG at 21 centers. Prior CAB...

Procedural Success and Outcomes With Increasing Use of Enabling Strategies for Chronic Total Occlusion Intervention

Original Research | By Kinnaird T, Gallagher S, British Cardiovascular Intervention Society and the National Institute for Cardiovascular Outcomes Research.

BACKGROUND - Enabling strategies (ESs) are increasingly used during percutaneous coronary intervention for chronic total occlusive disease (CTO-PCI), enhancing procedural success. Using the British Cardiovascular Society dataset, we examined changes in the use of ESs and procedural/clinical outcomes for CTO-PCI. METHODS AND RESULTS - ESs were defined as intravascular ultrasound, rotational/...

Chronic Total Occlusion Interventions: Update on Current Tips and Tricks

Review Article | By Tajti P, Xenogiannis I, Brilakis ES et al.

PURPOSE OF REVIEW - To summarize novel techniques and developments in chronic total occlusion (CTO) percutaneous coronary intervention (PCI). RECENT FINDINGS - Using an algorithmic, step-by-step approach can help overcome several complex CTO lesions subsets, such as proximal cap ambiguity, ostial location, in-stent occlusion, bifurcations, balloon uncrossable and undilatable lesions. Sim...

Extreme Levels of Air Pollution Associated With Changes in Biomarkers of Atherosclerotic Plaque Vulnerability and Thrombogenicity in Healthy Adults

Original Research | By Xu H, Wang T, Liu S et al.

Prior Pacemaker Implantation and Clinical Outcomes in Patients With Heart Failure and Preserved Ejection Fraction

Original Research | By Shen L, Jhund PS, McMurray JJV et al.

OBJECTIVES - This study examined the relationship between prior pacemaker implantation and clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND - Conventional right ventricular pacing causes electrical and mechanical left ventricular dys-synchrony and may worsen left ventricular systolic dysfunction and HF. Whether conventional pacing is also associate...

Permanent pacemaker use among patients with heart failure and preserved ejection fraction: Findings from the Acute Decompensated Heart Failure National Registry (ADHERE) National Registry

Original Research | By Khazanie P, Hellkamp AS, Hernandez AF et al.

BACKGROUND - Heart failure with preserved ejection fraction may be associated with chronotropic incompetence, but little is known about the incidence and prevalence of permanent pacemaker use in this population or factors associated with its use. METHODS - We analyzed patients with heart failure with preserved ejection fraction (ie, left ventricular ejection fraction greater than 40%) from the ADHERE ...

Novel percutaneous interventional therapies in heart failure with preserved ejection fraction: an integrative review

Review Article | By Burlacu A, Simion P, Nistor I et al.

Heart failure with preservedejectionfraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertional dyspnea being its clinical manifestation. The increasing pressure from LA is not based on volume overload...

Nitrosative stress drives heart failure with preserved ejection fraction

Original Research | By Schiattarella GG, Altamirano F, Hill JA et al.

Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive stress in mice-elicited by a combination of high-fat diet and inhibition of constitutive nitric oxide synthase using Nω-nitro-L-arginine methyl ester (L-NAME)-recapitulates the numerous systemic and cardi...

Successful catheter ablation of electrical storm after myocardial infarction

Clinical Case Study | By Bänsch D, Oyang F, Antz M et al.

Acute Noncardiac Organ Failure in Acute Myocardial Infarction With Cardiogenic Shock

Original Research | By Vallabhajosyula S, Dunlay SM, Prasad A et al.

BACKGROUND - There are limited data on acute noncardiac multiorgan failure in cardiogenic shock complicating acute myocardial infarction (AMI-CS). OBJECTIVES - The authors sought to evaluate the 15-year national trends, resource utilization, and outcomes of single and multiple noncardiac organ failures in AMI-CS. METHODS - This was a retrospective cohort study of AMI-CS...