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动脉粥样硬化性心血管疾病预防

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Coronary calcification in the diagnosis of coronary artery disease High-risk plaque detected on coronary CT angiography predicts acute coronary syndromes independent of significant stenosis in acute chest pain: results from the ROMICAT-II trial Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis Primary Prevention of Sudden Cardiac Death Identifying coronary artery disease patients at risk for sudden and/or arrhythmic death: remaining limitations of the electrocardiogram From Focal Lipid Storage to Systemic Inflammation In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events Sleep quality and risk of coronary heart disease-a prospective cohort study from the English longitudinal study of ageing Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization Simple Electrocardiographic Measures Improve Sudden Arrhythmic Death Prediction in Coronary Disease
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Review Article2020 Aug;13(8):e010460.

JOURNAL：Circ Cardiovasc Imaging . Article Link

Association of White Matter Hyperintensities and Cardiovascular Disease: The Importance of Microcirculatory Disease

F Moroni, E Ammirati, AH Hainsworth et al. Keywords: arteries; brain; heart failure; microcirculation; stroke

ABSTRACT

Cardiac and cerebrovascular diseases are currently the leading causes of mortality and disability worldwide. Both the heart and brain display similar vascular anatomy, with large conduit arteries running on the surface of the organ providing tissue perfusion through an intricate network of penetrating small vessels. Both organs rely on fine tuning of local blood flow to match metabolic demand. Blood flow regulation requires adequate functioning of the microcirculation in both organs, with loss of microvascular function, termed small vessel disease (SVD) underlying different potential clinical manifestations. SVD in the heart, known as coronary microvascular dysfunction, can cause chronic or acute myocardial ischemia and may lead to development of heart failure. In the brain, cerebral SVD can cause an acute stroke syndrome known as lacunar stroke or more subtle pathological alterations of the brain parenchyma, which may eventually lead to neurological deficits or cognitive decline in the long term. Coronary microcirculation cannot be visualized in vivo in humans, and functional information can be deduced by measuring the coronary flow reserve. The diagnosis of cerebral SVD is largely based on brain magnetic resonance imaging, with white matter hyperintensities, microbleeds, and brain atrophy reflecting key structural changes. There is evidence that such structural changes reflect underlying cerebral SVD. Here, we review interactions between SVD and cardiovascular risk factors, and we discuss the evidence linking cerebral SVD with large vessel atheroma, atrial fibrillation, heart failure, and heart valve disease.
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