CBS 2019
CBSMD教育中心
中 文

Other Relevant Articles

Abstract

Recommended Article

Triage Considerations for Patients Referred for Structural Heart Disease Intervention During the Coronavirus Disease 2019 (COVID-19) Pandemic: An ACC /SCAI Consensus Statement A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure From Nonclinical Research to Clinical Trials and Patient-registries: Challenges and Opportunities in Biomedical Research Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States Prognostic implication of lipidomics in patients with coronary total occlusion undergoing PCI Transcatheter Mitral-Valve Repair in Patients with Heart Failure 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society Timing and Causes of Unplanned Readmissions After Percutaneous Coronary Intervention: Insights From the Nationwide Readmission Database

Review Article2017 Mar 21;69(11):1451-1464.

JOURNAL:J Am Coll Cardiol. Article Link

A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure

Mitter SS, Shah SJ, Thomas JD. Keywords: Doppler; LV relaxation; echocardiography; heart failure with preserved ejection fraction

ABSTRACT


Diastolic dysfunction represents a combination of impaired left ventricular (LV) relaxation, restoration forces, myocyte lengthening load, and atrial function, culminating in increased LV filling pressures. Current Doppler echocardiography guidelines recommend using early to late diastolic transmitral flow velocity (E/A) to assess diastolic function, and E to early diastolic mitral annular tissue velocity (E/e') to estimate LV filling pressures. Although both parameters have important diagnostic and prognostic implications, they should be interpreted in the context of a patient's age and the rest of the echocardiogram to describe diastolic function and guide patient management. This review discusses: 1) the physiological basis for the E/A and E/e' ratios; 2) their roles in diagnosing diastolic dysfunction; 3) prognostic implications of abnormalities in E/A and E/e'; 4) special scenarios of the E/A and E/e' ratios that are either useful or challenging when evaluating diastolic function clinically; and 5) their usefulness in guiding therapeutic decision making.