CBS 2019
CBSMD教育中心
中 文

推荐文献

Abstract

Recommended Article

SCAI Expert Consensus Statement Update on Best Practices for Transradial Angiography and Intervention CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic Screening for Atrial Fibrillation With ECG: USPSTF Recommendation Long-Term Outcomes in Women and Men Following Percutaneous Coronary Intervention Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD Radial Versus Femoral Access for Coronary Interventions Across the Entire Spectrum of Patients With Coronary Artery Disease: A Meta-Analysis of Randomized Trials Long-term Survival following Multivessel Revascularization in Patients with Diabetes (FREEDOM Follow-On Study)
|<<... 2 3 4 5 6 7 8 ...>>|

Review Article2017 Aug 1;70(5):590-606.

JOURNAL：J Am Coll Cardiol. Article Link

Translational Perspective on Epigenetics in Cardiovascular Disease

van der Harst P, de Windt LJ, Chambers JC Keywords: EWAS; HAT; HDAC; RNA; histones; methylation

ABSTRACT

A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease. The epigenome provides a mechanistic link between environmental exposures and gene expression profiles ultimately leading to disease. The authors discuss the current evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics to cardiovascular disease. Furthermore, the potential targets provided by the epigenome for the development of future diagnostics, preventive strategies, and therapy for cardiovascular disease are reviewed. Finally, the authors provide some suggestions for future directions.



>CBS CBS 2019

> CBS 2019 REGISTRATION

> CBS 2019 PROGRAM

> CBS 2019 CALL FOR SCIENCE

> CBS 2019 SPOTLIGHTS

 CBSMD

> CBSMD WEBSITE REGISTRATION

> EDUCATION CENTER

> RECOMMANDED PAPER

> TOP 10 RESEARCH PAPER

> PRE-READING

CBS 2019 CBS 2019 FACULTY Education Resource CBSMD Scientific Library
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top