CBS 2019
CBSMD教育中心
中 文

推荐文献

Abstract

Recommended Article

A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes Association of Coronary Anatomical Complexity With Clinical Outcomes After Percutaneous or Surgical Revascularization in the Veterans Affairs Clinical Assessment Reporting and Tracking Program Drug-coated balloons for small coronary artery disease (BASKET-SMALL 2): an open-label randomised non-inferiority trial Association Between Living in Food Deserts and Cardiovascular Risk Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

Review Article2017 Mar 21;69(11):1451-1464.

JOURNAL:J Am Coll Cardiol. Article Link

A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure

Mitter SS, Shah SJ, Thomas JD. Keywords: Doppler; LV relaxation; echocardiography; heart failure with preserved ejection fraction

ABSTRACT

Diastolic dysfunction represents a combination of impaired left ventricular (LV) relaxation, restoration forces, myocyte lengthening load, and atrial function, culminating in increased LV filling pressures. Current Doppler echocardiography guidelines recommend using early to late diastolic transmitral flow velocity (E/A) to assess diastolic function, and E to early diastolic mitral annular tissue velocity (E/e') to estimate LV filling pressures. Although both parameters have important diagnostic and prognostic implications, they should be interpreted in the context of a patient's age and the rest of the echocardiogram to describe diastolic function and guide patient management. This review discusses: 1) the physiological basis for the E/A and E/e' ratios; 2) their roles in diagnosing diastolic dysfunction; 3) prognostic implications of abnormalities in E/A and E/e'; 4) special scenarios of the E/A and E/e' ratios that are either useful or challenging when evaluating diastolic function clinically; and 5) their usefulness in guiding therapeutic decision making.