CBS 2019
CBSMD教育中心
English

科学研究

科研文章

荐读文献

Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT Proteomics to Improve Phenotyping in Obese Patients with Heart Failure with Preserved Ejection Fraction Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main and Multivessel Coronary Artery Disease: Do We Have the Evidence? Haptoglobin genotype: a determinant of cardiovascular complication risk in type 1 diabetes Usefulness of intravascular ultrasound to predict outcomes in short-length lesions treated with drug-eluting stents 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Transcatheter Mitral Valve Replacement in Patients with Heart Failure and Secondary Mitral Regurgitation: From COAPT Trial Long-term outcomes following mini-crush versus culotte stenting for the treatment of unprotected left main disease: insights from the Milan and New-Tokyo (MITO) registry Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial
|<<... 109 110 111 112 113 114 115 ...>>|

Clinical TrialVolume 11, Issue 15, August 2018

JOURNAL：JACC Cardiovasc Interv. Article Link

Sex Differences in Adenosine-Free Coronary Pressure Indexes - A CONTRAST Substudy

SV Shah, FM Zimmermann, NP Johnson et al. Keywords: contrast fractional flow reserve; fractional flow reserve; sex differences

ABSTRACT

OBJECTIVES - The goal of this study was to investigate sex differences in adenosine-free coronary pressure indexes.


BACKGROUND - Several adenosine-free coronary pressure wire indexes have been proposed to assess the functional significance of coronary artery lesions; however, there is a theoretical concern that sex differences may affect diagnostic performance because of differences in resting flow and distal myocardial mass.

METHODS - In this CONTRAST (Can Contrast Injection Better Approximate FFR Compared to Pure Resting Physiology?) substudy, contrast fractional flow reserve (cFFR), obtained during contrast-induced submaximal hyperemia, the instantaneous wave-free ratio (iFR), and distal/proximal coronary pressure ratio (Pd/Pa) were compared with fractional flow reserve (FFR) in 547 men and 216 women. Using FFR ≤0.8 as a reference, the diagnostic performance of each index was compared.

RESULTS - Men and women had similar diameter stenosis (p = 0.78), but women were less likely to have FFR ≤0.80 than men (42.5% vs. 51.5%, p = 0.04). Sensitivity was similar among cFFR, iFR, and Pd/Pa when comparing women and men, respectively (cFFR, 77.5% vs. 75.3%; p = 0.69; iFR, 84.9% vs. 79.4%; p = 0.30; Pd/Pa, 78.8% vs. 77.3%; p = 0.78). cFFR was more specific than iFR or Pd/Pa regardless of sex (cFFR, 94.3% vs. 95.8%; p = 0.56; iFR, 75.6% vs. 80.1%; p = 0.38; Pd/Pa, 80.6% vs. 78.7%; p = 0.69). By receiver-operating characteristic curve analysis, cFFR provided better diagnostic accuracy than resting indexes irrespective of sex (p ≤ 0.0001).

CONCLUSIONS - Despite the theoretical concern, the diagnostic sensitivity and specificity of cFFR, iFR, and Pd/Pa did not differ between the sexes. Irrespective of sex, cFFR provides the best diagnostic performance.
>CBS CBS 2019

> CBS 2019

> CBS 2019 注册

> CBS 2019 会议日程

> CBS 2019 学术征集

> CBS 2019 热点

 CBSMD

> CBSMD 网站注册

> 教育中心

> 荐读文献

> Top 10 阅读文献

> 文献导读
CBS 2019 CBS 2019 主席团 教育中心 科研动态
Copyright ⓒ CBS MD Nanjing China. All rights reserved. 京ICP备16025898号-11
联系我们| Top