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Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label，blinded-outcome，randomised trial
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Clinical Trial2017 Aug 22;318(8):713-720.

JOURNAL：JAMA. Article Link

Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Felker GM, Anstrom KJ1, Adams KF et al. Keywords: Natriuretic Peptide–Guided Therapy; RCT; usual care; Hospitalization; Cardiovascular Mortality ; Heart Failure and Reduced Ejection Fraction

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