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Prospective, large-scale multicenter trial for the use of drug-coated balloons in coronary lesions: The DCB-only All-Comers Registry Management of pulmonary hypertension from left heart disease in candidates for orthotopic heart transplantation Characteristics of stent thrombosis in bifurcation lesions analysed by optical coherence tomography Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation The impact of downstream coronary stenoses on fractional flow reserve assessment of intermediate left main disease Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation One Versus 2-stent Strategy for the Treatment of Bifurcation Lesions in the Context of a Coronary Chronic Total Occlusion: A Multicenter Registry Therapeutic efficacy of paclitaxel-coated balloon for de novo coronary lesions with diameters larger than 2.8 mm Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial
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紫杉醇涂层球囊的最新研究进展

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支架内再狭窄仍是个临床难题，紫杉醇涂层球囊（Paclitaxel-coated balloons，PCBs）不失为一种替代方案。以下为PCBs的最新研究证据：


2019年1月新鲜出炉的“Clinical and angiographic outcomes of coronary dissection after paclitaxel-coated balloon angioplasty for small vessel coronary artery disease”纳入了单中心≤ 2.8mm的小冠脉血管病变，试图解释PCB即可经造影明确的冠脉夹层的发生机制及分型，并开展了术后长于6个月的临床随访，以进一步观察冠脉夹层的进展。


“Optical Coherence Tomography Predictors for Recurrent Restenosis After Paclitaxel-Coated Balloon Angioplasty for Drug-Eluting Stent Restenosis”介绍了经PCB-Angioplasty治疗DES-ISR后复发再狭窄的OCT影像学发现，6个月后发生复发再狭窄病变处的组织异质性更高，再狭窄病变处的最小官腔、支架面积、支架膨胀程度等指标显著不足。


“Long-term outcomes after treatment of bare-metal stent restenosis with paclitaxel-coated balloon catheters or everolimus-eluting stents: 3-year follow-up of the TIS clinical study”比较了3年PEB和DES在治疗BMS-ISR的长期疗效。


德国亚琛Schröder等回顾性完成了两种PCB术后一年MACE的比较分析“Long-term clinical outcomes after treatment of stent restenosis with two drug-coated balloons”采用单中心、非随机设计回顾性获取了单中心两种PCBs一年的MACE事概率（15.0 and 15.8% (P=0.879) for the BTHC-PCB and iopromide-based PCB groups）和1年TLR、心梗、心源性死亡事件概率（分别为9.6 versus 11.8%, P=0.622; 5.3 versus 3.9%, P=0.640; and 5.3 versus 3.9%, P=0.640）。


“Comparative efficacy of two paclitaxel-coated balloons with different excipient coatings in patients with coronary in-stent restenosis: A pooled analysis of the Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In-Stent Restenosis 3 and 4 trial”比较了PCB两种药用辅料BTHC-PCB (n=127)和 iopromide-PCB（n=137）置入6-8个月随访造影终点和1年临床终点。


“Therapeutic efficacy of paclitaxel-coated balloon for de novo coronary lesions with diameters larger than 2.8 mm”前瞻性地对以2.8mm为血管直径为分组阈值，在238例原发病变中评价紫杉醇涂层球囊的安全性和有效性。


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