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Age-specific gender differences in early mortality following ST-segment elevation myocardial infarction in China Effect of improved door-to-balloon time on clinical outcomes in patients with ST segment elevation myocardial infarction Prognostic Value of Fractional Flow Reserve Measured Immediately After Drug-Eluting Stent Implantation Skeletal muscle mitochondrial oxidative phosphorylation function in idiopathic pulmonary arterial hypertension: in vivo and in vitro study Optical coherence tomography findings: insights from the “randomised multicentre trial investigating angiographic outcomes of hybrid sirolimus-eluting stents with biodegradable polymer compared with everolimus-eluting stents with durable polymer in chronic total occlusions” (PRISON IV) trial Precision Medicine in TAVR: How to Select the Right Device for the Right Patient Trends and Impact of Door-to-Balloon Time on Clinical Outcomes in Patients Aged <75, 75 to 84, and ≥85 Years With ST-Elevation Myocardial Infarction 2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention and the 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infa Robotics in percutaneous cardiovascular interventions Anatomical plaque and vessel characteristics are associated with hemodynamic indices including fractional flow reserve and coronary flow reserve: A prospective exploratory intravascular ultrasound analysis
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CIT2019 - 最新临床研究亮点

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CIT2019 - Research Spotlights
高危出血患者PCI治疗策略
LEADERS FREE Ⅱ Trail - 现有指南推荐非出血高风险的ACS患者接受PCI治疗后DAPT治疗时间持续12个月。高出血风险患者接受置入DES支架的PCI治疗后，可考虑将P2Y12抑制剂治疗缩短至 3～6个月（Ⅱb类推荐）。

2016年德国埃森大学医院Christoph K. Naber教授曾在EuroPCR上汇报了置入二代DES BioFreedom BA9药物涂层支架（Drug Coated Stent，DCS）介入治疗后进行1个月DAPT治疗相较于金属支架的有效性及安全性。
Biolimus-A9 polymer-free coated stent in high bleeding risk patients with acute coronary syndrome: a Leaders Free ACS sub-study
http://www.cbsmd.org/CBS2017CMS/scientificresearch.php?cid=127&id=1998&oldpage=1&ordertype=hits&page=1

LEADERS FREE研究对高出血风险因子的界定：
1) 年龄≥75岁；
2) PCI术后接受口服抗凝药物；
3) 无法耐受＞30天的DAPT治疗;
4. 重要的手术相关指标包括长病变和复杂病变（即B2 & C型病变）。

预告CIT2019大会上，Naber教授将进一步汇报LEADERS FREE Ⅱ研究评估高出血风险患者药物涂层支架置入术后进行1个月DAPT的临床预后结果。
 
影像学指导PCI
ULTIMATE Trail - 在经诊断为无症状缺血、稳定或不稳定心绞痛或>24小时因胸痛入院的心肌梗死（包含STEMTI和NSTEMTI）的符合药物洗脱支架置入条件的全患者中证实了在理想药物洗脱支架置入的血管内超声（IVUS）指导下的DES置入相较于冠脉造影指导来说，不仅可辅助术者更准确地评估斑块内纤维、纤维脂质混合、坏死核和钙化等四种组织，优化置入效果，还可最终改善简单病变、甚至复杂病变PCI患者的预后。

理想的药物洗脱支架置入的IVUS标准，即：
1）DES植入后支架段最小管腔面积>5.0mm2，或大于90%的远端参考血管的最小管腔面积；
2）支架近端或远端5mm内的最大斑块负荷<50%;
3）无深达中层且存在长度超过3mm的夹层。

"Intravascular Ultrasound-Guided Versus Angiography-Guided Implantation of Drug-Eluting Stent in All-Comers: The ULTIMATE trial"
http://www.cbsmd.org/CBS2017CMS/scientificresearch.php?cid=112&id=1254&oldpage=1&ordertype=posttime&page=1

"CBSMD专访——ULTIMATE研究者张俊杰谈IVUS之过去、现在和未来"
http://www.cbsmd.org/CBS2017CMS/newsshow.php?cid=4&id=1620

预告本届CIT2019大会上，张俊杰教授将进一步汇报ULTIMATE Trail亚组分析及荟萃分析结果。
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