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Percutaneous Support Devices for Percutaneous Coronary Intervention Left Ventricular Assist Devices for Lifelong Support Association of Thrombus Aspiration With Time and Mortality Among Patients With ST-Segment Elevation Myocardial Infarction: A Post Hoc Analysis of the Randomized TOTAL Trial Coronary flow velocity reserve predicts adverse prognosis in women with angina and noobstructive coronary artery disease: resultsfrom the iPOWER study 稳定性冠心病诊断与治疗指南 Cardiovascular Biomarkers and Imaging in Older Adults: JACC Council Perspectives 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Guiding Principles for Chronic Total Occlusion Percutaneous Coronary Intervention Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months versus aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicenter, open-label, randomized superiority trial

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血管重构之正性重构

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经冠脉CTA,冠脉磁共振(coronary magnetic resonance imaging, coronary MRI), OCT或IVUS等腔内影像,NIRS联合IVUS,可从不同角度观测到贯穿于心脏的各条蜿蜒曲折,宽窄不一的血管成像。若血管外弹力膜(extravascular elastic membrane, EEM)面积介于病变部位近端和远端EEM面积之间,则表示无血管重构。血管重构包括正性重构(positive remodeling)和负性重构(negative remodeling, 若面积大于病变部位近端和远端EEM的面积,称为血管正性重构,反之当EEM面积小于病变部位近端和远端EEM面积,称为血管负性重构,参数上可通过重构指数,即病变部位EEM面积与近远端EEM面积平均值的比(Remodeling Index,RI)来表示,RI>1.0 表示正性重构, RI<1.0 表示负性重构。


IVUS获得的有关血管正性重构的发生率、疾病表现及血管正性重构与临床预后间的关系的相关文献按发表时间排列如下,

  • 1. 2014年原创研究 -“Positive remodeling at 3 year follow up is associated with plaque-free coronary wall segment at baseline: a serial IVUS study 

  • 2. 2014年临床研究 - “Impact of Positive and Negative Lesion Site Remodeling on Clinical Outcomes : Insights From PROSPECT”

  • 3. 2014年随访数据分析 -“Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement

  • 4. 2015年亚组分析 - Comparison of plaque characteristics in narrowings with ST-elevation myocardial infarction (STEMI), non-STEMI/unstable angina pectoris and stable coronary artery disease (from the ADAPT-DES IVUS Substudy)

  • 5. 2017年原创研究 - Relation between baseline plaque features and subsequent coronary artery  remodeling determined by optical coherence tomography and intravascular ultrasound

  • 6. 2018年原创研究 -“ Coronary plaque redistribution after stent implantation is determined by lipid composition: A NIRS-IVUS analysis”

  • 7. 2018年原创研究 -Intravascular Ultrasound and Angioscopy Assessment of Coronary Plaque Components in Chronic Totally Occluded Lesions 

  • 8. 2019年原创研究 - Novel predictors of late lumen enlargement in distal reference segments after successful recanalization of coronary chronic total occlusion