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Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women Anticoagulation After Surgical or Transcatheter Bioprosthetic Aortic Valve Replacement Prospective application of pre-defined intravascular ultrasound criteria for assessment of intermediate left main coronary artery lesions results from the multicenter LITRO study Accuracy of Fractional Flow Reserve Derived From Coronary Angiography 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Association of White Matter Hyperintensities and Cardiovascular Disease: The Importance of Microcirculatory Disease Association Between Depressive Symptoms and Incident Cardiovascular Diseases Why NOBLE and EXCEL Are Consistent With Each Other and With Previous Trials Transcatheter Aortic Valve Replacement in Patients With Multivalvular Heart Disease
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FDA Updates Prescribing Information For Alirocumab

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The U.S. Food and Drug Administration (FDA) has updated prescribing information for alirocumab (Praluent) as of April 26, 2019. Specifically, the updated prescribing information states that "Praluent is a PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody indicated:

  • to reduce the risk of myocardial infarction, stroke, and unstable angina requiring hospitalization in adults with established cardiovascular disease. (1.1)
  • as adjunct to diet, alone or in combination with other lipid-lowering therapies (e.g., statins, ezetimibe), for the treatment of adults with primary hyperlipidemia (including heterozygous familial hypercholesterolemia) to reduce low-density lipoprotein cholesterol LDL-C. (1.2)"


The FDA update follows data from the ODYSSEY OUTCOMES trial assessing the effect of adding Praluent to maximally-tolerated statins on cardiovascular outcomes in 18,924 patients who had an acute coronary syndrome (ACS) within a year of enrolling in the trial. The original results were published in theNew England Journal of Medicinein November 2018, with a recent subgroup analysis presented at ACC.19. For complete drug label information visit the FDA's DailyMed website.

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