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In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions OCT guidance during stent implantation in primary PCI: A randomized multicenter study with nine months of optical coherence tomography follow-up Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture Survival prospects of treatment naïve patients with Eisenmenger: a systematic review of the literature and report of own experience Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease Feasibility and efficacy of the ultrashort side branch dedicated balloon in coronary bifurcation stenting Superficial Calcium Fracture After PCI as Assessed by OCT Restricted access Mortality After Repeat Revascularization Following PCI or CABG for Left Main Disease: The EXCEL Trial
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JOURNAL：CBSMD Article Link

Percutaneous Left Atrial Appendage Occlusion: How Much Do We Know?

CBSMD

Pre-reading

  • Definition of percutaneous left artrail appendage occlusion
  • Indications for LAAO therapy

  • How to define study endpoints, stroke and classifications, transient ischemic attack, cardiovascular mortality, non-cardiovascular mortality, procedural mortality, immediate procedural mortality, systemic embolism, pericardial effusion, bleeding events etc.  




RCTs


Year 2009, "Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial"

confirmed the efficacy of percutaneous closure of the LAA with this device was non-inferior to that of warfarin therapy. Although there was a higher rate of adverse safety events in the intervention group than in the control group, events in the intervention group were mainly a result of periprocedural complications. Closure of the LAA might provide an alternative strategy to chronic warfarin therapy for stroke prophylaxis in patients with non-valvular atrial fibrillation.

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