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The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment Dual Antiplatelet Therapy Duration: Reconciling the Inconsistencies Sleep quality and risk of coronary heart disease-a prospective cohort study from the English longitudinal study of ageing Identifying coronary artery disease patients at risk for sudden and/or arrhythmic death: remaining limitations of the electrocardiogram Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF) Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis Heart Failure With Improved Ejection Fraction-Is it Possible to Escape One’s Past? Bridging the Gap Between Epigenetic and Genetic in PAH
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ConsensusAugust 2019

JOURNAL：EuroIntervention. Article Link

EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion – an update

Glikson M, Wolff R, Hindricks G et al. Keywords: catheter-based left atrial appendage occlusion; atrial fibrillation; stroke prevention

ABSTRACT

Chapter 1. Background and pathophysiology of thrombus formation in the left atrium

The rationale for the quest to close the left atrial appendage (LAA) for stroke prevention is composed of three elements: the concept that atrial fibrillation (AF) causes strokes, the concept that strokes are associated with thrombus formation in the LAA, and that these thrombi cause strokes by embolisation to the cerebral circulation.

There are strong data supporting an association between AF and stroke. The Framingham study following 5,070 patients over 34 years demonstrated an approximately fivefold higher stroke risk in individuals with AF than in those without1. Though ...
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