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Impact of myocardial supply area on the transstenotic hemodynamics as determined by fractional flow reserve Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR A Case of Pulmonary Hypertension Associated with Idiopathic Hypereosinophilic Syndrome Survival prospects of treatment naïve patients with Eisenmenger: a systematic review of the literature and report of own experience Pulmonary arterial hypertension in congenital heart disease: an epidemiologic perspective from a Dutch registry Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension The right ventricle in pulmonary hypertension
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Review ArticleVolume 75, Issue 21, June 2020

JOURNAL：JACC Article Link

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review

V Narayan, EW Thompson, B Demissei et al. Keywords: biomarkers; cancer; cardio-oncology; cardiovascular disease

ABSTRACT

Cardiovascular disease (CVD) and cancer are leading causes of morbidity and mortality worldwide. Although conventionally managed as separate disease processes, recent research has lent insight into compelling commonalities between CVD and cancer, including shared mechanisms for disease development and progression. In this review, the authors discuss several pathophysiological processes common to both CVD and cancer, such as inflammation, resistance to cell death, cellular proliferation, neurohormonal stress, angiogenesis, and genomic instability, in an effort to understand common mechanisms of both disease states. In particular, the authors highlight key circulating and genomic biomarkers associated with each of these processes, as well as their associations with risk and prognosis in both cancer and CVD. The purpose of this state-of-the-art review is to further our understanding of the potential mechanisms underlying cancer and CVD by contextualizing pathways and biomarkers common to both diseases.
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