CBS 2019
CBSMD教育中心
English

科学研究

科研文章

荐读文献

Impact of myocardial supply area on the transstenotic hemodynamics as determined by fractional flow reserve Apolipoprotein A-V is a potential target for treating coronary artery disease: evidence from genetic and metabolomic analyses Physiologic Characteristics and Clinical Outcomes of Patients With Discordance Between FFR and iFR Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy A Case of Pulmonary Hypertension Associated with Idiopathic Hypereosinophilic Syndrome Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension Pulmonary arterial hypertension in congenital heart disease: an epidemiologic perspective from a Dutch registry Survival prospects of treatment naïve patients with Eisenmenger: a systematic review of the literature and report of own experience The right ventricle in pulmonary hypertension

Review Article2020 Dec 18;105383.

JOURNAL:Pharmacol Res. Article Link

Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review

F Yarmohammadi, R Rezaee, AW Haye et al. Keywords: apoptosis; autophagy; cardiac damage; doxorubicin; inflammation

ABSTRACT

Doxorubicin (DOX) is a chemotherapeutic agent with marked, dose-dependent cardiotoxicity that leads to tachycardia, atrial and ventricular arrhythmia, and irreversible heart failure. Induction of the endoplasmic reticulum (ER) which plays a major role in protein folding and calcium homeostasis was reported as a key contributor to cardiac complications of DOX. This article reviews several chemical compounds that have been shown to regulate DOX-induced inflammation, apoptosis, and autophagy via inhibition of ER stress signaling pathways, such as the IRE1α/ASK1/JNK, IRE1α/JNK/Beclin-1, and CHOP pathways.