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Association of Coronary Anatomical Complexity With Clinical Outcomes After Percutaneous or Surgical Revascularization in the Veterans Affairs Clinical Assessment Reporting and Tracking Program The Prognostic Value of Exercise Echocardiography After Percutaneous Coronary Intervention Systems of Care for ST-Segment–Elevation Myocardial Infarction: A Policy Statement From the American Heart Association Large-Bore Radial Access for Complex PCI: A Flash of COLOR With Some Shades of Grey 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series Prevalence, Presentation and Treatment of 'Balloon Undilatable' Chronic Total Occlusions: Insights from a Multicenter US Registry Discharge Against Medical Advice After Percutaneous Coronary Intervention in the United States COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up Invasive Coronary Physiology After Stent Implantation: Another Step Toward Precision Medicine
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Review Article2021 Jun 4;PP.

JOURNAL：IEEE Trans Med Imaging. Article Link

Dynamic Myocardial Ultrasound Localization Angiography

P Cormier, J Poree, C Bourquin et al. Keywords: dynamic myocardial ultrasound localization angiography

ABSTRACT

Dynamic Myocardial Ultrasound Localization Angiography (MULA) is an ultrasound-based imaging modality destined to enhance the diagnosis and treatment monitoring of coronary pathologies. Current diagnosis methods of coronary artery disease focus on the observation of vessel narrowing in the coronary vasculature to assess the organ’s condition. However, we would strongly benefit from mapping and measuring flow from intramyocardial arterioles and capillaries as they are the direct vehicle of the myocardium blood income. With the advent of ultrafast ultrasound scanners, imaging modalities based on the localization and tracking of injected microbubbles allow for the subwavelength resolution imaging of an organ’s vasculature. Yet, the application of these vascular imaging modalities relies on an accumulation of cine loops of a region of interest undergoing no or minimal tissue motion. This work introduces the MULA framework that combines 1) the mapping of the dynamics of the microvascular flow using an ultrasound sequence triggered by the electrocardiogram with a 2) novel Lagrangian beamformer based on non-rigid motion registration algorithm to form images directly in the myocardium’s material coordinates and thus correcting for the large myocardial motion and deformation. Specifically, we show that this framework enables the non-invasive imaging of the angioarchitecture and dynamics of intramyocardial flow in vessels as small as a few tens of microns in the rat’s beating heart in vivo.
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