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Frequency, predictors, and prognosis of ejection fraction improvement in heart failure: an echocardiogram-based registry study 2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized With Heart Failure: A Report of the American College of Cardiology Solution Set Oversight Committee Phenomapping for Novel Classification of Heart Failure With Preserved Ejection Fraction A three-vessel virtual histology intravascular ultrasound analysis of frequency and distribution of thin-cap fibroatheromas in patients with acute coronary syndrome or stable angina pectoris Stopping or continuing clopidogrel 12 months after drug-eluting stent placement: the OPTIDUAL randomized trial Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies The spectrum of heart failure: value of left ventricular ejection fraction and its moving trajectories DAPT, Our Genome and Clopidogrel Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association Timing of intervention in asymptomatic patients with valvular heart disease

Review Article2021 Jun 4;PP.

JOURNAL:IEEE Trans Med Imaging. Article Link

Dynamic Myocardial Ultrasound Localization Angiography

P Cormier, J Poree, C Bourquin et al. Keywords: dynamic myocardial ultrasound localization angiography

ABSTRACT

Dynamic Myocardial Ultrasound Localization Angiography (MULA) is an ultrasound-based imaging modality destined to enhance the diagnosis and treatment monitoring of coronary pathologies. Current diagnosis methods of coronary artery disease focus on the observation of vessel narrowing in the coronary vasculature to assess the organ’s condition. However, we would strongly benefit from mapping and measuring flow from intramyocardial arterioles and capillaries as they are the direct vehicle of the myocardium blood income. With the advent of ultrafast ultrasound scanners, imaging modalities based on the localization and tracking of injected microbubbles allow for the subwavelength resolution imaging of an organ’s vasculature. Yet, the application of these vascular imaging modalities relies on an accumulation of cine loops of a region of interest undergoing no or minimal tissue motion. This work introduces the MULA framework that combines 1) the mapping of the dynamics of the microvascular flow using an ultrasound sequence triggered by the electrocardiogram with a 2) novel Lagrangian beamformer based on non-rigid motion registration algorithm to form images directly in the myocardium’s material coordinates and thus correcting for the large myocardial motion and deformation. Specifically, we show that this framework enables the non-invasive imaging of the angioarchitecture and dynamics of intramyocardial flow in vessels as small as a few tens of microns in the rat’s beating heart in vivo.