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Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label，blinded-outcome，randomised trial
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Original Research17 July 2021

JOURNAL：Cardiovascular Research Article Link

Nicotine promotes vascular calcification via intracellular Ca21-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

P Petsophonsakul, M Burgmaier, B Willems et al. Keywords: smoking; mechanisms; ASCVD; calification; vitamine K2

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