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Disturbed shear stress promotes atherosclerosis through TRIM21-regulated MAPK6 degradation and consequent endothelial inflammation Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label，blinded-outcome，randomised trial
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Clinical Trial2017 Oct 10;70(15):1875-1886.

JOURNAL：J Am Coll Cardiol. Article Link

Pulmonary Artery Pressure-Guided Management of Patients With Heart Failure and Reduced Ejection Fraction

Givertz MM, Stevenson LW, CHAMPION Trial Investigators et al. Keywords: clinical outcomes; guideline-directed medical therapy; hemodynamic monitoring

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