CBS 2019
CBSMD教育中心
English

科学研究

科研文章

荐读文献

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older Systemic microvascular dysfunction in microvascular and vasospastic angina Sex- and Race-Related Differences in Characteristics and Outcomes of Hospitalizations for Heart Failure With Preserved Ejection Fraction Plasma Ionized Calcium and Risk of Cardiovascular Disease: 106 774 Individuals from the Copenhagen General Population Study Nocturnal thoracic volume overload and post-discharge outcomes in patients hospitalized for acute heart failure Clinical Impact of Valvular Heart Disease in Elderly Patients Admitted for Acute Coronary Syndrome: Insights From the Elderly-ACS 2 Study Burden of Cardiovascular Diseases in China, 1990-2016: Findings From the 2016 Global Burden of Disease Study Extreme Levels of Air Pollution Associated With Changes in Biomarkers of Atherosclerotic Plaque Vulnerability and Thrombogenicity in Healthy Adults Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis

Original Research2011 Jan;6(6):768-72.

JOURNAL:EuroIntervention. Article Link

Assessment of the coronary calcification by optical coherence tomography

Kume T, Okura H, Kawamoto T et al. Keywords: coronary artery disease; IVUS; OCT

ABSTRACT

AIMS - Optical coherence tomography (OCT) can delineate calcified plaque without artefacts. The aim of this study was to evaluate the ability of OCT to quantify calcified plaque in ex vivo human coronary arteries.

METHODS AND RESULTS - Ninety-one coronary segments from 33 consecutive human cadavers were examined. By intravascular ultrasound (IVUS), 32 superficial calcified plaques, defined as the leading edge of the acoustic shadowing appears within the most shallow 50% of the plaque plus media thickness, were selected and compared with corresponding OCT and histological examinations. The area of calcification was measured by planimetry. IVUS significantly underestimated the area of calcification compared with histological examination (y = 0.39x + 0.14, r = 0.78, p < 0.001). Although OCT slightly underestimated the area of calcification (y = 0.67x + 0.53, r = 0.84, p < 0.001), it showed a better correlation with histological examination than IVUS.

CONCLUSIONS - Both OCT and IVUS underestimated the area of calcification, but OCT estimates of the area of calcification were more accurate than those estimated by IVUS. Thus, OCT may be a more useful clinical tool to quantify calcified plaque.