Original Research | By Stokke TM, Hasselberg NE, Remme EW et al.
BACKGROUND - Preserved left ventricular (LV) ejection fraction (EF) and reduced myocardial strain are reported in patients with hypertrophic cardiomyopathy, ischemic heart disease, diabetes mellitus, and more. OBJECTIVES - The authors performed a combined mathematical and echocardiographic study to understand the inconsistencies between EF and ...
Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes
Original Research | By Shah KS, Xu H, Fonarow GC et al.
BACKGROUND - Patients with heart failure (HF) have a poor prognosis and are categorized by ejection fraction (EF). OBJECTIVES - This study sought to characterize differences in outcomes in patients hospitalized with heart failure with preserved ejection fraction (HFpEF) (EF ≥50%), heart failure with&n...
Original Research | By Lloyd JW, Nishimura RA, Eleid MF et al.
BACKGROUND - Low-gradient severe aortic stenosis (LGSAS) with preserved ejection fraction (EF) is incompletely understood. The influence of arterial afterload and diastolic dysfunction on the hemodynamic presentation of LGSAS remains unknown. OBJECTIVES - The authors sought to determine the acute hemodynamic response&n...
Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure
Original Research | By Jakovljevic DG, Yacoub MH, Schueler S et al.
BACKGROUND - Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation, as destination therapy, or in some patients, as a bridge to recovery. OBJECTIVES - This study evaluated whether patients und...
Left Ventricular Assist Devices for Lifelong Support
Review Article | By Pinney SP, Anyanwu AC, Lala A et al.
Continuous-flow left ventricular assist devices (LVADs) have revolutionized advanced heart failure care. These compact, fully implantable heart pumps are capable of providing meaningful increases in survival, functional capacity, and quality of life. Implantation volumes continue to grow, but several challenges remain to be overcome before LVADs will be considered as the therapy of choice for all patients with advanced...
Mode of Death in Heart Failure With Preserved Ejection Fraction
Review Article | By Vaduganathan M, Patel RB, Butler J et al.
Little is known about specific modes of death in patients with heart failure with preserved ejection fraction(HFpEF). Herein, the authors critically appraise the current state of data and offer potential future directions. They conducted a systematic review of 1,608 published HFpEF papers from January 1, 1985, to December 31, 2015, which yielded 8 randomized clinical trials and 24 epidemiological stud...
Clinical Trial | By Givertz MM, Stevenson LW, CHAMPION Trial Investigators et al.
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Guideline | By Ponikowski P, Voors AA, ESC Scientific Document Group. et al.
A Test in Context: E/A and E/e' to Assess Diastolic Dysfunction and LV Filling Pressure
Review Article | By Mitter SS, Shah SJ, Thomas JD.
Diastolic dysfunction represents a combination of impaired left ventricular (LV) relaxation, restoration forces, myocyte lengthening load, and atrial function, culminating in increased LV filling pressures. Current Doppler echocardiography guidelines recommend using early to late diastolic transmitral flow velocity (E/A) to assess diastolic function, and E to early diastolic mitral annular tissue velocity (E/e') to estimate LV filling pressure...