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Impact of Pre-Existing and New-Onset Atrial Fibrillation on Outcomes After Transcatheter Aortic Valve Replacement

Original Research | By A Mentias, M Saad, S Girotra et al.

OBJECTIVES - This study sought to evaluate impact of new-onset and pre-existing atrial fibrillation (AF) on transcatheter aortic valve replacement (TAVR) long-term outcomes compared with patients without AF.   BACKGROUND - Pre-existing and new-onset AF in patients undergoing TAVR are associated with poor outcomes.   METHODS - The study identified 72,660 patients ≥...

Evolocumab for Early Reduction of LDL Cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)

Original Research | By KC Koskinas, S Windecker, G Pedrazzini et al.

BACKGROUND - Although guidelines recommend in-hospital initiation of high-intensity statin therapy in patients with acute coronary syndromes (ACS), low-density lipoprotein cholesterol (LDL-C) target levels are frequently not attained. Evolocumab, a rapidly acting, potent LDL-C–lowering drug, has not been studied in the acute phase of ACS.   OBJECTIVES - The purpose of this study was to assess the fea...

Association of Smoking Status With Long‐Term Mortality and Health Status After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry

Original Research | By Qintar M, Li Z, Vemulapalli S et al.

Anatomical Attributes of Clinically Relevant Diagonal Branches in Patients with Left Anterior Descending Coronary Artery Bifurcation Lesions

Original Research | By Jeon WK, Park J, Koo BK et al.

AIMS - This study aimed to investigate the anatomical attributes determining myocardial territory of diagonal branches and to develop prediction models for clinically relevant branches using myocardial perfusion imaging (MPI) and coronary CT angiography (CCTA). METHODS AND RESULTS - The amount of ischemia and subtended myocardial mass of diagonal branches were quantified using MPI by percent is...

Safety and efficacy of a self-expanding versus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial

Clinical Trial | By Lanz J, Kim WK, SCOPE I investigators.

BACKGROUND - Transcatheter aortic valve replacement (TAVR) is the preferred treatment option for older patients with symptomatic severe aortic stenosis. Differences in the properties of available TAVR systems can affect clinical outcomes. Among patients undergoing TAVR, we compared the self-expanding ACURATE neo TAVR system with the balloon-expandable SAPIEN 3 TAVR system with regard to early safety ...

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

Original Research | By Tardif JC, Kouz S, Waters DD et al.

BACKGROUND - Experimental and clinical evidence support the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis. METHODS - We performed a randomized, double-blind trial involving patients recruited within 30 days after a myocardial infarction. The patients were randoml...

Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age: Insights From DAPA-HF

Editorial | By Martinez FA, Serenelli M, Nicolau JC et al.

Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial

Clinical Trial | By MN Kosiborod, PJhund, KF Docherty et al.

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

Clinical Trial | By McMurray JJV, SD Solomon, DAPA-HF Committees and Investigators.

BACKGROUND - In patients with type 2 diabetes, inhibitors of sodium–glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the presence or absence of type 2 diabetes. METHODS - In this phas...

Best Practices for the Prevention of Radial Artery Occlusion After Transradial Diagnostic Angiography and Intervention An International Consensus Paper

Review Article | By I Bernat, A Aminian, the RAO International Group.

Transradial access (TRA) is increasingly used worldwide for percutaneous interventional procedures and associated with lower bleeding and vascular complications than transfemoral artery access. Radial artery occlusion (RAO) is the most frequent post-procedural complication of TRA, restricting the use of the same radial artery for future procedures and as a conduit for coronary artery bypass graft. The authors review recent advances in the ...

By Article Type

Original Research 785
Review Article 294
Clinical Case Study 28
Clinical Trial 415
Perspective 9
Guideline 50

By Year

2019 10

By Journal

N Engl J Med. 1
N Engl J Med. 1
Lancet. 1
JACC Cardiovasc Interv. 2
J Am Heart Assoc. 1
J Am Coll Cardiol. 1
EuroIntervention. 1
Circulation. 2

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