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Management of Percutaneous Coronary Intervention Complications: Algorithms From the 2018 and 2019 Seattle Percutaneous Coronary Intervention Complications Conference

Original Research | By JA Doll , RS Hira , KE Kearney et al.

Complications of percutaneous coronary intervention (PCI) may have significant impact on patient survival and healthcare costs. PCI procedural complexity and patient risk are increasing, and operators must be prepared to recognize and treat complications, such as perforations, dissections, hemodynamic collapse, no-reflow, and entrapped equipment. Unfortunately, few resources exist to train operators in PCI complication management. Uncerta...

Chimney technique in a TAVR-in-TAVR procedure with high risk of left main artery ostium occlusion

Clinical Case Study | By A Dibie, Q Landolff, A Veugeois et al.

An 87-year-old woman was referred to our centre for a valve-in-valve transcatheter aortic valve replacement (TAVR). She underwent a TAVR procedure with implantation of a SAPIEN XT 26 mm (Edwards Lifesciences) bioprosthesis 7 years before but subsequently developed symptomatic aortic valve failure (mean gradient = 64 mmHg). Pre-procedural computed tomography (CT) scan identified a low height between the valvular...

Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization

Clinical Trial | By K Oyama, RHM Furtado, BA Bergmark et al.

BACKGROUND - Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors induce plaque regression and reduce the risk of coronary revascularization overall. OBJECTIVES - To evaluate the ability of PCSK9 inhibitors to reduce the risk of complex coronary atherosclerosis requiring revascularization. METHODS - FOURIER was a randomized trial of the PCSK9 inhibitor evolocum...

Ticagrelor versus clopidogrel in elective percutaneous coronary intervention (ALPHEUS): a randomised, open-label, phase 3b trial

Clinical Trial | By J Silvain, B Lattuca, ALPHEUS investigators et al.

Sleep quality and risk of coronary heart disease-a prospective cohort study from the English longitudinal study of ageing

Original Research | By CX Song, R Zhang, KF Dou et al.

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Consensus | By J Borén, MJ Chapman, RM Krauss et al.

Long-term outcomes after myocardial infarction in middle-aged and older patients with congenital heart disease-a nationwide study

Original Research | By M Fedchenko, Z Mandalenakis, KW Giang et al.

Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy

Clinical Trial | By P Thavendiranathan, T Negishi, SUCCOUR investigators et al.

BACKGROUND - In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardio-protective therapy (CPT) is constrained by the low sensitivity of EF for minor changes in LV function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT. OBJECTIV...

Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

Clinical Trial | By TJ Ford, D Corcoran, S Padmanabhan et al.

Association of White Matter Hyperintensities and Cardiovascular Disease: The Importance of Microcirculatory Disease

Review Article | By F Moroni, E Ammirati, AH Hainsworth et al.

Cardiac and cerebrovascular diseases are currently the leading causes of mortality and disability worldwide. Both the heart and brain display similar vascular anatomy, with large conduit arteries running on the surface of the organ providing tissue perfusion through an intricate network of penetrating small vessels. Both organs rely on fine tuning of local blood flow to match metabolic demand. Blood flow regulation requires adequate functioning...

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Original Research 785
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2020 10

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Lancet. 1
J Am Coll Cardiol. 2
Eur Heart J. 4
Circ Cardiovasc Interv. 1
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