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Clinical applications of machine learning in the diagnosis, classification, and prediction of heart failure

Review Article | By CR Olsen, RJ Mentz, KJ Anstrom et al.

Machine learning and artificial intelligence are generating significant attention in the scientific community and media. Such algorithms have great potential in medicine for personalizing and improving patient care, including in the diagnosis and management of heart failure. Many physicians are familiar with these terms and the excitement surrounding them, but many are unfamiliar with the basics of these algorithms and how they are applied to ...

Long-Term Outcomes of Patients With Mediastinal Radiation–Associated Coronary Artery Disease Undergoing Coronary Revascularization With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting

Letter | By AN Dunn, E Donnellan, DR Johnston et al.

Coronary Angiography in Patients With Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation: A Systematic Review and Meta-Analysis

Review Article | By BR Verma, V Sharma, S Shekhar et al.

OBJECTIVES - The authors conducted a meta-analysis to study clinical outcomes in patients who underwent early versus nonearly coronary angiography (CAG) in the setting of out-of-hospital cardiac arrest (OHCA) without ST-segment elevation. BACKGROUND - The benefit of performing early CAG in patients with OHCA without STE remains disputed. METHODS - MEDLINE, Embase, and the Coch...

Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis

Original Research | By JK Forrest, B Ramlawi, GM Deeb et al.

IMPORTANCE - The outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients with bicuspid aortic valve stenosis have not been studied in a large scale, multicentered, prospective fashion. OBJECTIVE - To evaluate the procedural safety, efficacy, and 30-day outcomes of TAVR in patients with bicuspid aortic stenosis at low surgical risk. DESIGN, SETTING, AND PART...

Bridging the Gap Between Epigenetic and Genetic in PAH

Expert Opinion | By François Potus, PhD; Stephen L. Archer, MD, FACC

Quick Takes Tet methylcytosine dioxygenase 2 (TET2), an epigenetic regulator that demethylates cytosine, is mutated in both idiopathic pulmonary arterial hypertension (PAH) and associated PAH. TET2 expression is ubiquitously decreased in peripheral blood cells of paitents with both idiopathic and associated PAH. TET2 depletion creates a pro-inflammatory phenotype in patients with PAH and mice w...

Decreased inspired oxygen stimulates de novo formation of coronary collaterals in adult heart

Original Research | By A Aghajanian, H Zhang, JE Faber et al.

RATIONALE - Collateral vessels lessen myocardial ischemia when acute or chronic coronary obstruction occurs. It has long been assumed that although native (pre-existing) collaterals enlarge in obstructive disease, new collaterals do not form in the adult. However, the latter was recently shown to occur after coronary artery ligation. Understanding the signals that drive this process is challenged by the difficulty in studying collateral vessels di...

Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery: A Meta-analysis

Review Article | By M Gaudino, I Hameed, ME Farkouh et al.

IMPORTANCE - Mortality is a common outcome in trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG). Controversy exists regarding whether all-cause mortality or cardiac mortality is preferred as a study end point, because noncardiac mortality should be unrelated to the treatment.   OBJECTIVE - To evaluate the difference in all-cause and cause-specific mortalit...

Effect of Pre-Hospital Crushed Prasugrel Tablets in Patients with STEMI Planned for Primary Percutaneous Coronary Intervention: The Randomized COMPARE CRUSH Trial

Clinical Trial | By GJ Vlachojannis , JM Wilschut , RF Vogel et al.

Percutaneous Coronary Intervention for Vulnerable Coronary Atherosclerotic Plaque

Clinical Trial | By GW. Stone, A Maehara, and for the PROSPECT ABSORB Investigators.

BACKGROUND - Acute coronary syndromes most commonly arise from thrombosis of lipid-rich coronary atheromas that have large plaque burden despite angiographically appearing mild. OBJECTIVES - We sought to examine the outcomes of percutaneous coronary intervention (PCI) of non-flow-limiting vulnerable plaques. METHODS - Three-vessel imaging was performed with a combinati...

Closure of Iatrogenic Atrial Septal Defect Following Transcatheter Mitral Valve Repair: The Randomized MITHRAS Trial

Clinical Trial | By P Lurz , M Unterhuber , KP Rommel et al.

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Original Research 785
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Clinical Trial 415
Perspective 9
Guideline 50

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2020 10

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JAMA Intern Med. 1
JAMA Cardiol. 1
JACC: Cardiovascular Interventions 1
JACC 1
J Mol Cell Cardio. 1
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