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How Will the Transition to hs-cTn Affect the Diagnosis of Type 1 and 2 MI?

Expert Opinion | By Y Sandoval; FS Apple; AS Jaffe

Cardiac troponin (cTn) is the preferred cardiac biomarker used for the detection of myocardial injury.1 It can be used to facilitate the exclusion of acute myocardial infarction (MI) or its inclusion when there is a rising and/or falling pattern of cTn with at least one value >99th percentile.1 High-sensitivity cTn assays have been used clinically outside the United States for years. In January 2017, the US Food and Drug Administration (FDA) clea...

Reappraisal of Reported Genes for Sudden Arrhythmic Death: An Evidence-Based Evaluation of Gene Validity for Brugada Syndrome

Original Research | By S. Mohsen Hosseini, Raymond Kim, Sharmila Udupa

BACKGROUND - Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years considerable variability has existed in the study design and quality of evidence supporting reported gene-disease associations raising concerns of the validity of many published disease-causing gene...

A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions

Clinical Trial | By Werner GS, Martin-Yuste V, EUROCTO trial investigators.

AIMS - The clinical value of percutaneous coronary intervention (PCI) for chronic coronary total occlusions (CTOs) is not established by randomized trials. This study should compare the benefit of PCI vs. optimal medical therapy (OMT) on the health status in patients with at least one CTO. METHOD AND RESULTS - Three hundred and ninety-six patients were enrolled in a prospective randomized, multi...

Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation The mSToPS Randomized Clinical Trial

Clinical Trial | By SR Steinhubl, J Waalen, AM Edwards et al.

IMPORTANCE - Opportunistic screening for atrial fibrillation (AF) is recommended, and improved methods of early identification could allow for the initiation of appropriate therapies to prevent the adverse health outcomes associated with AF. OBJECTIVE -  To determine the effect of a self-applied wearable electrocardiogram (ECG) patch in detecting AF and the clinical consequences associated with such a det...

Intravascular ultrasound-guided drug-eluting stent implantation is associated with improved clinical outcomes in patients with unstable angina and complex coronary artery true bifurcation lesions

Clinical Trial | By Chen L, Xu T, Chen SL et al.

Stenting coronary artery bifurcation lesion is associated with suboptimal clinical results. Clinical improvement by intravascular ultrasound (IVUS) guided bifurcation stenting is controversial because small-side-branch (SB), low-risk patients and false bifurcations were included in previous studies that had no exact IVUS criteria for optimal stent expansion. We sought determine whether IVUS guidance is superior to angiography guidance for ...

Chronic Total Occlusion Percutaneous Coronary Intervention: Evidence and Controversies

Review Article | By Tajti P, Brilakis ES.

Coronary chronic total occlusions (CTOs) are defined as 100% occlusions with TIMI (Thrombolysis in Myocardial Infarction) 0 flow with at least a 3‐month duration. Treatment options for patients with coronary CTOs include lifestyle changes and medications (as is appropriate for all patients with coronary artery disease) and coronary revascularization with either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (C...

Angiography Alone Versus Angiography Plus Optical Coherence Tomography to Guide Percutaneous Coronary Intervention Outcomes From the Pan-London PCI Cohort

Original Research | By DA Jones, KS Rathod, S Koganti et al.

OBJECTIVES - This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). BACKGROUND - Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. ...

Angiographic derived endothelial shear stress: a new predictor of atherosclerotic disease progression

Clinical Trial | By Bourantas CV, Ramasamy A, Karagiannis A et al.

AIMS - To examine the efficacy of angiography derived endothelial shear stress (ESS) in predicting atherosclerotic disease progression. METHODS AND RESULTS - Thirty-five patients admitted with ST-elevation myocardial infarction that had three-vessel intravascular ultrasound (IVUS) immediately after revascularization and at 13 months follow-up were included. Three dimensional (3D) reconstruction of the no...

Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study

Clinical Trial | By Stone PH, Saito S, PREDICTION Investigators.

BACKGROUND - Atherosclerotic plaques progress in a highly individual manner. The purposes of the Prediction of Progression of Coronary Artery Disease and Clinical Outcome Using Vascular Profiling of Shear Stress and Wall Morphology (PREDICTION) Study were to determine the role of local hemodynamic and vascular characteristics in coronary plaque progression and to relate plaque changes to clinical events. ...

Stroke Rates Following Surgical Versus Percutaneous Coronary Revascularization

Original Research | By Head SJ, Milojevic M, Daemen J et al.

BACKGROUND - Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are used for coronary revascularization in patients with multivessel and left main coronary artery disease. Stroke is among the most feared complications of revascularization. Due to its infrequency, studies with large numbers of patients are required to detect differences in stroke rates between CABG and PCI. ...

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Original Research 785
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JAMA Cardiol. 1
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Int J Cardiovasc Imaging. 1
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Eur Heart J Cardiovasc Imaging. 1
Circulation. 2
Am J Cardiol. 1

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