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Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease

Clinical Trial | By Gorter TM, Obokata M, Borlaug BA et al.

AIMS - Pulmonary hypertension (PH) and pulmonary vascular disease (PVD) are common and associated with adverse outcomes in heart failure with preserved ejection fraction (HFpEF). Little is known about the impact of PVD on the pathophysiology of exercise intolerance. METHODS AND RESULTS - Heart failure with preserved ejection fraction patients (n = 161) with elevated pulmonary capillary we...

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Clinical Trial | By Ridker PM, Everett BM, CANTOS Trial Group et al.

BACKGROUND - Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS - We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous m...

Inflammation: A New Target For CAD Treatment and Prevention

Clinical Trial | By Alfred A. Bove, MD, PHD, MACC

Neoatherosclerosis in Patients With Coronary Stent Thrombosis: Findings From Optical Coherence Tomography Imaging (A Report of the PRESTIGE Consortium)

Clinical Trial | By Joner M, Koppara T, Prevention of PRESTIGE Investigators et al.

OBJECTIVES - The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography. BACKGROUND - In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation. METHODS - Angiography and intravascular optical coher...

Characteristics of stent thrombosis in bifurcation lesions analysed by optical coherence tomography

Clinical Trial | By Bechiri MY, Souteyrand G, Lefèvre T et al.

AIMS - This work aimed to investigate a cohort of patients presenting with stent thrombosis (ST) explored by optical coherence tomography (OCT) to identify the underlying mechanical abnormalities in case of bifurcation lesions. METHODS AND RESULTS - The PESTO study was a prospective national registry involving 29 French catheterisation facilities. Patients with acute coronary syndromes were pr...

Coronary Atherosclerosis T1-Weighed Characterization With Integrated Anatomical Reference: Comparison With High-Risk Plaque Features Detected by Invasive Coronary Imaging

Clinical Trial | By Xie Y, Kim YJ, Li D et al.

OBJECTIVES - The aim of this work is the development of coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) technique and the validation by comparison with high-risk plaque features (HRPF) observed on intracoronary optical coherence tomography (OCT) and invasive coronary angiography. BACKGROUND - T1-weighted cardiac magnetic resonance with or wi...

Coronary Artery Intraplaque Microvessels by Optical Coherence Tomography Correlate With Vulnerable Plaque and Predict Clinical Outcomes in Patients With Ischemic Angina

Original Research | By Xu T, Lin L, Chen SL et al.

Atherosclerosis is a chronic inflammatory disease characterized by increased requirements of oxygen supply with cells in the plaque, which will promote the invasion of the vessel wall by the vasa vasorum and lead to the formation of newly restructured microvessels (MVs) in the plaque. MV formation is reported to be correlated with the vulnerability of plaques. We analyzed the prevalence and clinical relevance of MVs in patients with coronary...

Comparison of Coronary Intimal Plaques by Optical Coherence Tomography in Arteries With Versus Without Internal Running Vasa Vasorum

Original Research | By Amano H, Koizumi M, Okubo R et al.

It has been reported that the internal running vasa vasorum (VV) was associated with plaque vulnerability, and microchannels in optical coherence tomography (OCT) are consistent pathologically with VV. We investigated plaque vulnerability and incidence of slow flow during percutaneous coronary intervention of the internal longitudinal running VV. Subjects were 71 lesions that underwent OCT before percutaneous coronary intervention. Internal...

Randomized study to evaluate sirolimus-eluting stents implanted at coronary bifurcation lesions

Clinical Trial | By Colombo A, Moses JW, Morice MC et al.

BACKGROUND - A sirolimus-eluting stent (Cypher, Cordis Corp) has been reported to markedly decrease restenosis in selected lesions; higher-risk lesions, including coronary bifurcations, have not been studied. METHODS AND RESULTS - This prospective study evaluated the safety and efficacy of sirolimus-eluting stents for treatment of coronary bifurcation lesions. Patients were randomly assigned to either ste...

Drug-eluting stent implantation in patients with acute coronary syndrome - the Activity of Platelets after Inhibition and Cardiovascular Events: Optical Coherence Tomography (APICE OCT) study

Original Research | By Chieffo A, Buchanan GL, Colombo A et al.

AIMS - To our knowledge, no randomised study has compared rates of uncovered stent struts in everolimus (EES) vs. new-generation zotarolimus-eluting (ZES-R) stents in acute coronary syndrome (ACS). The aim of our study was to evaluate the completeness of neointimal coverage with optical coherence tomography (OCT) in ACS patients treated with drug-eluting stents (DES) comparing EES versus new-generation ZES-R. ...

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Am J Cardiol. 1
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