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Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions

Original Research | By Torii R, Stettler R, Bourantas CV et al.

OBJECTIVE - To examine the implications of endothelial shear stress (ESS) distribution in the formation of neoatherosclerotic lesions.   METHODS - Thirty six patients with neoatherosclerotic lesions on optical coherence tomography (OCT) were included in this study. The OCT data were used to reconstruct coronary anatomy. Blood flow simulation was performed in the models reconstructed from the stent borders...

Evolving insights into the role of local shear stress in late stent failure from neoatherosclerosis formation and plaque destabilization

Editorial | By Stone PH, Coskun AU, Croce KJ.

Please click on the "Article Link" on the right side to access this Editorial.

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

Clinical Trial | By Bhatt DL, Steg PG, REDUCE-IT Investigators.

BACKGROUND - Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride levels, but data are needed to determine its effects on ischemic events.   METHODS - We performed a multicenter, randomized, double-blind, placebo-controlled trial involving patients with established cardiovascular diseas...

Left Main Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Prior Cerebrovascular Disease: Results From the EXCEL Trial

Original Research | By Diamond J, Madhavan MV, Stone GW et al.

OBJECTIVES - The aim of this study was to determine whether high-risk patients with left main coronary artery disease (LMCAD) and prior cerebrovascular disease (CEVD) preferentially benefit from revascularization by percutaneous coronary intervention (PCI) compared with coronary artery bypass grafting (CABG). BACKGROUND - Patients with known CEVD requiring revascularization are often referred to ...

Outcomes of patients with and without baseline lipid-lowering therapy undergoing revascularization for left main coronary artery disease: analysis from the EXCEL trial

Original Research | By Chen S, Redfors B, Stone GW et al.

OBJECTIVES - There is a paucity of data on the effect of baseline lipid-lowering therapy (LLT) in patients undergoing revascularization for left main (LM) coronary artery disease (CAD). We compared outcomes for patients with LMCAD randomized to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) according to the presence of baseline LLT in the EXCEL trial. PATIENTS A...

New-onset atrial fibrillation after PCI and CABG for left main disease: insights from the EXCEL trial and additional studies

Review Article | By Kosmidou I, Stone GW.

PURPOSE OF REVIEW - To provide an up-to-date review of recent trials examining the incidence and prognostic impact of new-onset atrial fibrillation (NOAF) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) and the impact of postprocedural NOAF compared to nonsurgical atrial fibrillation. RECENT FINDIN...

Radial versus femoral artery access in patients undergoing PCI for left main coronary artery disease: analysis from the EXCEL trial

Original Research | By Chen S, Redfors B, Stone GW et al.

AIMS - We sought to compare clinical outcomes and procedural characteristics with transradial access (TRA) versus transfemoral access (TFA) in patients who were treated with PCI for left main (LM) coronary artery disease. METHODS AND RESULT - The EXCEL trial was a prospective, international, open-label, multicentre trial that randomised 1,905 patients with LM disease and SYN...

Left Main Revascularization With PCI or CABG in Patients With Chronic Kidney Disease: EXCEL Trial

Original Research | By Giustino G, Mehran R, Stone GW et al.

BACKGROUND - The optimal revascularization strategy for patients with left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. OBJECTIVES - This study investigated the comparative effectiveness of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in patients with LMCAD and low or intermediate anatomical complexity...

ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 Appropriate Use Criteria for Multimodality Imaging in the Assessment of Cardiac Structure and Function in Nonvalvular Heart Disease: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and the Society of Thoracic Surgeons

| By Writing Group Members, JU Doherty, S Kort, R Mehran et al.

Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women

Clinical Trial | By P Dewan, R Rørth, JJV McMurray et al.

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Original Research 785
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N Engl J Med. 1
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J Am Coll Cardiol. 3
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