IVUS Guidance for Coronary Revascularization: When to Start, When to Stop?
Refractory Angina: From Pathophysiology to New Therapeutic Nonpharmacological Technologies
Review Article | By G Gallone, L Baldetti, G Tzanis et al.
Despite optimal combination of guideline-directed anti-ischemic therapies and myocardial revascularization, a substantial proportion of patients with stable coronary artery disease continues to experience disabling symptoms and is often referred as “no-option.” The appraisal of the pathways linking ischemia to symptom perception indicates a complex model of heart-brain interactions in the generation of the subjective anginal experience and inspir...
A Controlled Trial of Rivaroxaban After Transcatheter Aortic-Valve Replacement
Clinical Trial | By GD Dangas, JGP Tijssen, the GALILEO Investigators et al.
BACKGROUND - Whether the direct factor Xa inhibitor rivaroxaban can prevent thromboembolic events after transcatheter aortic-valve replacement (TAVR) is unclear. METHODS - We randomly assigned 1644 patients without an established indication for oral anticoagulation after successful TAVR to receive rivaroxaban at a dose of 10 mg daily (with aspirin at a dose of 75 to 100 mg daily for the first 3 months)...
Reduced Leaflet Motion after Transcatheter Aortic-Valve Replacement
Clinical Trial | By OD Backer, GD Dangas, the GALILEO-4D Investigators et al.
BACKGROUND - Subclinical leaflet thickening and reduced leaflet motion of bioprosthetic aortic valves have been documented by four-dimensional computed tomography (CT). Whether anticoagulation can reduce these phenomena after transcatheter aortic-valve replacement (TAVR) is not known. METHODS - In a substudy of a large randomized trial, we randomly assigned patients who had undergone successful T...
Clinical Trial | By M Konigstein, PC Smits, MP Love et al.
OBJECTIVES - This study sought to determine clinical outcomes between treatment groups over long-term follow-up. BACKGROUND - The safety and efficacy of a ridaforolimus-eluting stent (RES) was evaluated in the BIONICS (BioNIR Ridaforolimus-Eluting Coronary Stent System in Coronary Stenosis) and NIREUS (BioNIR Ridaforolimus Eluting Coronary Stent System [BioNIR] Euro...
OBJECTIVES - This study sought to compare outcomes between biodegradable polymer drug-eluting stent (BP-DES) and second-generation durable polymer drug-eluting stent (DP-DES) implantations for acute myocardial infarction (MI) using a nationwide dataset. BACKGROUND - Data regarding outcomes of BP-DES versus second-generation DP-DES are inconclusive. METHODS - ...
Clinical Trial | By Y Onuma, Y Honda, T Asano et al.
OBJECTIVES - The aim of this study was to investigate the vascular responses and fates of the scaffold after bioresorbable vascular scaffold (BVS) implantation using multimodality imaging. BACKGROUND - Serial comprehensive image assessments after BVS implantation in the context of a randomized trial have not yet been reported. METHODS - In the ABSORB Japan trial,...
Noninvasive Imaging for the Evaluation of Diastolic Function: Promises Fulfilled
Original Research | By M Przewlocka-Kosmala, TH Marwick, H Yang et al.
OBJECTIVES - This study investigated the prognostic utility of left ventricular (LV) untwisting (UT) in the elderly patients at risk of heart failure (HF). BACKGROUND - LV UT mechanics represent a unique combination of LV filling linking ventricular relaxation and suction. The value of this parameter in the prediction of outcomes in patients at risk of HF is unclear. MET...