Clinical Trial | By TA Zelniker, M Ardissino, F Andreotti et al.
Clinical Trial | By AM Maznyczka, PJ McCartney, KG Oldroyd et al.
BACKGROUND - The index of microcirculatory resistance (IMR) of the infarct-related artery and left ventricular end-diastolic pressure (LVEDP) are acute, prognostic biomarkers in patients undergoing primary percutaneous coronary intervention. The clinical significance of IMR and LVEDP in combination is unknown. METHODS - IMR and LVEDP were prospectively measured in a prespeci...
Original Research | By HR Reynolds, A Maehara, RY Kwong et al.
Original Research | By R Modolo, M van Mourik, PW Serruys et al.
BACKGROUND - Quantitative assessment of regurgitation after TAVR through aortography using videodensitometry is simple, reproducible, and validated in vitro, in vivo, in clinical trials, and in “real-world” patients. However, thus far the assessment has been done offline. METHODS - This was a single center, prospective, proof-of-principle, feasibility study. One hundred consecutive patients with aortic stenosis a...
Review Article | By M Valgimigli , R Mehran, SIDNEY Collaboration et al.
OBJECTIVES - The aim of this study was to compare ticagrelor monotherapy with dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with drug-eluting stents. BACKGROUND - The role of abbreviated DAPT followed by an oral P2Y12 inhibitor after PCI remains uncertain. METHODS - Two randomized trials, including 14,628 patients undergoing PCI...
Clinical Trial | By S-J Lee, JY Cho, TICO Investigators et al.
OBJECTIVES - The aim of this study was to assess whether the effects of ticagrelor monotherapy after 3-month dual-antiplatelet therapy (DAPT) are consistent among patients presenting with ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction, and unstable angina treated with drug-eluting stents. BACKGROUND - Ticagrelor monotherapy after short-term ...
Clinical Trial | By Z Ge, JJ Zhang, SL Chen et al.
BACKGROUND - Current guidelines recommend administering dual antiplatelet therapy (DAPT) for 12 months to patients with acute coronary syndromes (ACS) and without contraindications after drug-eluting stent (DES) implantation. A recent study reported that 3 months of DAPT followed by ticagrelor monotherapy is effective and safe in ACS patients undergoing DES implantation compared with the standard duration of DAPT. Ho...
Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality
Original Research | By DJA Jenkins, M Dehghan, PURE Study Investigators et al.
BACKGROUD - Most data regarding the association between the glycemic index and cardiovascular disease come from high-income Western populations, with little information from non-Western countries with low or middle incomes. To fill this gap, data are needed from a large, geographically diverse population. METHODS - This analysis includes 137,851 participants between the ages of 35 and 70 years living on five cont...