Original Research | By Yang Y, CAMI Registry study group.
Animal and imaging study evidence favors early reperfusion for acute myocardial infarction. However, in clinical trials, the effect of symptom-onset-to-balloon (S2B) time on clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) has been inconsistent. Moreover, there are few data regarding the ischemic time in China. A total of 3,877 consecuti...
Original Research | By Makam RC, Erskine N, Goldberg RJ et al.
Optimization of medical therapy during discharge planning is vital for improving patient outcomes after hospitalization for acute myocardial infarction (AMI). However, limited information is available about recent trends in the prescribing of evidence-based medical therapies in these patients, especially from a population-based perspective. We describe decade-long trends in the discharge prescribing of aspirin, angiotensin-converting enzyme inhibit...
Original Research | By Zhang Y, Yang S, Liu X et al.
The degree of adherence to current guidelines for clinical management of ST-segment elevation myocardial infarction (STEMI) is known in developed countries and large Chinese cities, but in predominantly rural areas information is lacking. We assessed the application of early reperfusion therapy for STEMI in secondary and tertiary hospitals in Henan province in central China. Data were retrospectively collected from 5 secondary and 4 terti...
Correction of a pathogenic gene mutation in human embryos
Original Research | By Ma H, Marti-Gutierrez N, Mitalipov S et al.
Genome editing has potential for the targeted correction of germline mutations. Here we describe the correction of the heterozygous MYBPC3 mutation in human preimplantation embryos with precise CRISPR-Cas9-based targeting accuracy and high homology-directed repair efficiency by activating an endogenous, germline-specific DNA repair response. Induced double-strand breaks (DSBs) at ...
Association Between Living in Food Deserts and Cardiovascular Risk
Original Research | By Kelli HM, Hammadah M, Quyyumi AA et al.
BACKGROUND - Food deserts (FD), neighborhoods defined as low-income areas with low access to healthy food, are a public health concern. We evaluated the impact of living in FD on cardiovascular risk factors and subclinical cardiovascular disease (CVD) with the hypothesis that people living in FD will have an unfavorable CVD risk profile. We further ass...
Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
Original Research | By Sabatine MS, FOURIER Steering Committee and Investigators.
BACKGROUND - Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS - We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiova...
Clinical Trial | By M .Kosiborod, CVD-REAL Investigators and Study Group.
Original Research | By Puymirat E, Aissaoui N, FAST-MI investigators.
BACKGROUND - Elderly patients are underrepresented in acute myocardial infarction trials. Our aim was to determine whether, in elderly patients, changes in management in the past 15 years are associated with improved 1-year mortality after hospital admission for myocardial infarction. METHODS - We used data from 4 1-month French registries, conducted 5 years apart from 1995 to 2010, including 3389 elderly patients (...
Original Research | By Al'Aref SJ, Wong SC, Minutello RM et al.
BACKGROUND - Registry-driven data have shown a significant decrease in door-to-balloon (DTB) times in patients with ST-elevation myocardial infarction (STEMI) receiving percutaneous coronary intervention (PCI). We sought to determine the trends in reperfusion times (symptom-onset to door (SOTD) and DTB times) in patients presenting with STEMI across New York State. METHODS - We retrospectively ...