Clinical Case Study | By Murasato Y, Mori T, Okamura T et al.
A 67-year-old man with a 1,1,0 lesion in the left circumflex artery obtuse marginal branch bifurcation (Panel Aa), in which vessel references in the proximal, distal MV and SB were 3.2, 2.6, and 2.8 mm, respectively, underwent zotarolimus-eluting 2.75×12 mm stent (Medtronic, Minneapolis, MN, USA) implantation at 8 atm (Panel Ab). POT was performed with the stent delivery balloon at 12 atm with its distal marker located in t...
Management of left main disease: an update
Review Article | By Fajadet J, Capodanno D, Stone GW.
A severe narrowing of the left main coronary artery (LMCA), usually due to atherosclerosis, jeopardizes a large area of myocardium and increases the risk of major adverse cardiac events. Management strategies for LMCA disease include coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). In general, PCI offers more rapid recovery and a lower early adverse event rate, whereas CABG offers a more durable p...
Clinical Trial | By Hamon M, Lemesle G, Bauters C et al.
OBJECTIVES - The authors sought to describe the incidence, determinants, and outcome of elective coronary revascularization (ECR) in patients with stable coronary artery disease (CAD). BACKGROUND - Observational data are lacking regarding the practice of ECR in patients with stable CAD receiving modern secondary prevention. METHODS - The authors analyzed coronary revascularization p...
Clinical Trial | By M Rashid, C Lawson, J Potts et al.
OBJECTIVES - The authors sought to determine the relationships between left radial access (LRA) or right radial access (RRA) and clinical outcomes using the British Cardiovascular Intervention Society (BCIS) database. BACKGROUND - LRA has been shown to offer procedural advantages over RRA in percutaneous coronary intervention (PCI) although few data exist from a national perspective around its use and...
Review Article | By V Pasceri, G Patti, F Pelliccia et al.
OBJECTIVES - The aim of this study was to compare complete revascularization with a culprit-only strategy in patients presenting with ST-segment elevation myocardial infarction (MI) and multivessel disease by a meta-analysis of randomized trials. BACKGROUND - Although several trials have compared complete with culprit-only revascularization in ST-segment elevation MI, it remains unclear whether ...
Clinical Trial | By Falkentoft AC, Rørth R, Iversen K et al.
BACKGROUND - Midregional proadrenomedullin (MR-proADM) has demonstrated prognostic potential after myocardial infarction (MI). Yet, the prognostic value of MR-proADM at admission has not been examined in patients with ST-segment-elevation MI (STEMI). METHODS AND RESULTS - The aim of this substudy, DANAMI-3 (The Danish Study of Optimal Acute Treatment of Patients with ST-s...
Fractional Flow Reserve–Guided PCI for Stable Coronary Artery Disease
Clinical Trial | By De Bruyne B, Pijls NH, FAME 2 Trial Investigators et al.
BACKGROUND - We hypothesized that in patients with stable coronary artery disease and stenosis, percutaneous coronary intervention (PCI) performed on the basis of the fractional flow reserve (FFR) would be superior to medical therapy. METHODS - In 1220 patients with stable coronary artery disease, we assessed the FFR in all stenoses that were visible on angiography. Patients who had at least one stenosis wi...
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
Clinical Trial | By De Bruyne B, Pijls NH, FAME 2 Trial Investigators et al.
BACKGROUND - The preferred initial treatment for patients with stable coronary artery disease is the best available medical therapy. We hypothesized that in patients with functionally significant stenoses, as determined by measurement of fractional flow reserve (FFR), percutaneous coronary intervention (PCI) plus the best available medical therapy would be superior to the best available medical therapy alone. METHO...
Five-Year Outcomes with PCI Guided by Fractional Flow Reserve
Clinical Trial | By Xaplanteris P, Fournier S, FAME 2 Trial Investigators et al.
BACKGROUND - We hypothesized that fractional flow reserve (FFR)–guided percutaneous coronary intervention (PCI) would be superior to medical therapy as initial treatment in patients with stable coronary artery disease. METHODS - Among 1220 patients with angiographically significant stenoses, those in whom at least one stenosis was hemodynamically significant (FFR, ≤0.80) were randomly assigned to FFR-gui...