Obesity, Diabetes, and Acute Coronary Syndrome: Differences Between Asians and Whites
Review Article | By Koshizaka M, Lopes RD, Newby LK et al.
BACKGROUND - Most diabetes and cardiovascular studies have been conducted in white patients, with data being extrapolated to other population groups. METHODS - For this analysis, patient-level data were extracted from 5 randomized clinical trials in patients with acute coronary syndrome; we compared obesity levels between Asian and white populations, stratified by diabetes status. By using an adjusted Cox proportional hazards ...
Clinical Trial | By Lavi S, Iqbal J, Cairns JA et al.
BACKGROUND - The safety and efficacy of drug eluting stents (DES) in the setting of ST elevation myocardial infarction (STEMI) is not well established. METHODS - In the TOTAL trial, patients presenting with STEMI were randomized to routine thrombectomy versus PCI alone. In this post-hoc analysis, propensity matching was used to assess relative safety and efficacy according to type of stent used. ...
The HACD4 haplotype as a risk factor for atherosclerosis in males
Clinical Trial | By Zivotić I, Djurić T, Zivković M et al.
The 9p21.3 region is rich in regulatory elements and the variants in this region had been robustly associated with carotid plaque (CP) and coronary artery disease (CAD). Recently, the HACD4 was detected as one of the six 9p21.3 differentially expressed genes associated with accelerated atherosclerosis and greater mean lesion area in the Athsq1 congenic mice. We aimed to investigate association of two potentially regulatory HACD4 variants (rs3621256...
Original Research | By Yeo KK, Zheng H, Chow KY et al.
AIMS - Acute myocardial infarction (AMI) and stroke are important causes of mortality and morbidity. Our aims are to determine the comparative epidemiology of AMI and ischaemic stroke; and examine the differences in cardiovascular outcomes or mortality occurring after an AMI or stroke. METHODS AND RESULTS - The Singapore National Registry of Diseases Office collects countrywide data on AMI, stroke, and m...
Clinical Trial | By Chen SL, Xu B, Han YL et al.
OBJECTIVES - The study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions. BACKGROUND - DK crush and Culotte stenting were reported to be effective for treatment of coronary bifurcation lesions. Howev...
Clinical Trial | By Teeuwen K, Spoormans EM, Bennett J et al.
AIMS - The PRISON IV trial investigated the next-generation sirolimus-eluting stent (SES) with ultra-thin struts and biodegradable polymer against the second-generation everolimus-eluting stent (EES) with thin struts and durable polymer in patients with successfully recanalised chronic total occlusions (CTO). In this study, we examined the secondary optical coherence tomography endpoints. METHODS AND RESULTS...
Clinical Trial | By Hakim D, Chatterjee A, Leesar MA et al.
BACKGROUND - Bench models of coronary bifurcation lesions demonstrated that the proximal optimization technique (POT) expanded the stent and opened the side branch (SB). We investigated the role of POT guided by intravascular ultrasound on the main vessel (MV) stent expansion and SB fractional flow reserve (FFR) in patients with coronary bifurcation lesion. METHODS AND RESULTS - In 40 patients with corona...
Clinical Trial | By Toma A, Stähli BE, Gick M et al.
Successful recanalization of chronic total occlusions (CTO) has been associated with improved survival. Data on outcomes in patients with left ventricular (LV) systolic dysfunction undergoing percutaneous coronary intervention for CTO, however, are scarce. Between January 2005 and December 2013, a total of 2,002 consecutive patients undergoing elective CTO percutaneous coronary intervention at a tertiary care center were divided into patients with ...
Clinical Trial | By Toma A, Stähli B, Gebhard C et al.
AIMS - Periprocedural myocardial injury (PMI) is frequently observed after percutaneous coronary interventions (PCI) for chronic total occlusion (CTO). We investigated the prognostic impact of PMI with the antegrade or the retrograde crossing technique. METHODS AND RESULTS - A total of 1909 patients undergoing CTO PCI were stratified according to the presence/absence of PMI (elevation of cardiac...