Coronary fractional flow reserve in bifurcation stenoses: what have we learned?
Review Article | By Lee JM, Koo BK, Kumsars I et al.
Fractional flow reserve (FFR) is a useful tool for the evaluation of coronary bifurcation lesions. FFR can guide treatment strategy, simplify the procedure and reduce unnecessary complex interventions. However, the application of FFR to complex bifurcation lesions requires a comprehensive understanding of its roles and potential pitfalls. Furthermore, FFR should be interpreted in the context of complex bifurcation anatomy and physio...
Clinical Trial | By H Thiele , U Zeymer, IABPSHOCK II Trial investigators.
BACKGROUND - In current international guidelines the recommendation for intra-aortic balloon pump (IABP) use has been downgraded in cardiogenic shock complicating acute myocardial infarction on the basis of registry data. In the largest randomised trial (IABP-SHOCK II), IABP support did not reduce 30 day mortality compared with control. However, previous trials in cardiogenic shock showed a mortality benefit only at exte...
Clinical Trial | By Abdin A, Pöss J, Thiele H et al.
BACKGROUND - Limited data from observational retrospective studies suggest an association between glucose levels and prognosis of patients with cardiogenic shock (CS). The aim of this study was to investigate the prognostic role of glucose at admission in patients with acute myocardial infarction (AMI) complicated by CS included in the largest CS trial to date, the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHO...
Original Research | By Saad M, Fuernau G, Thiele H et al.
AIMS - The aim of the current study was to investigate the impact of a chronic total occlusion (CTO) in a non-infarct-related coronary artery (non-IRA) on one-year mortality and occurrence of cardiac arrhythmia in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI). METHODS AND RESULTS - In a retrospective sub-analysis of the Intraaortic Balloon Pump in Cardio...
Original Research | By de Waha S, Schoene K, Thiele H et al.
BACKGROUND - Aim of the current study was to analyse the impact of atrial fibrillation (AF) on prognosis in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI), which has never been investigated yet. METHODS - The current analysis is a substudy of the IABP-SHOCK II trial. Patients were grouped according to the presence or absence of AF. The primary endpoint was...
Risk Stratification for Patients in Cardiogenic Shock After Acute Myocardial Infarction
Original Research | By Zeymer U, Werdan K, Thiele H et al.
BACKGROUND - Current guidelines recommend immediate multivessel percutaneous coronary intervention (PCI) in patients with cardiogenic shock, despite the lack of randomised trials. We sought to investigate the use and impact on outcome of multivessel PCI in comparison to culprit lesion only PCI in a retrospective analysis in patients with cardiogenic shock complicating acute myocardial infarction. METHO...
Original Research | By Fuernau G, Fengler K, Thiele H et al.
BACKGROUND - In myocardial infarction without cardiogenic shock (CS), the affected coronary vessel has significant influence on the final infarct size and patient prognosis. CS data on this relation are scarce. The objective of this study was to determine the prognostic relevance of the culprit lesion location in patients with CS complicating acute myocardial infarction. METHODS - In the Intraaortic B...