BACKGROUND - Enabling strategies (ESs) are increasingly used during percutaneous coronary intervention for chronic total occlusive disease (CTO-PCI), enhancing procedural success. Using the British Cardiovascular Society dataset, we examined changes in the use of ESs and procedural/clinical outcomes for CTO-PCI. METHODS AND RESULTS - ESs were defined as intravascular ultrasound, rotational/...
Chronic Total Occlusion Interventions: Update on Current Tips and Tricks
Review Article | By Tajti P, Xenogiannis I, Brilakis ES et al.
PURPOSE OF REVIEW - To summarize novel techniques and developments in chronic total occlusion (CTO) percutaneous coronary intervention (PCI). RECENT FINDINGS - Using an algorithmic, step-by-step approach can help overcome several complex CTO lesions subsets, such as proximal cap ambiguity, ostial location, in-stent occlusion, bifurcations, balloon uncrossable and undilatable lesions. Sim...
Original Research | By Huded CP, Kumar A, Johnson M et al.
BACKGROUND - Systems to improve ST-segment-elevation myocardial infarction (STEMI) care have traditionally focused on improving door-to-balloon time. However, prompt guideline-directed medical therapy and transradial primary percutaneous coronary intervention (PCI) are also associated with reduced STEMI mortality. The incremental prognostic value of each facet of STEMI care on clinical outcomes within a STEMI system of...
Original Research | By Shen L, Jhund PS, McMurray JJV et al.
OBJECTIVES - This study examined the relationship between prior pacemaker implantation and clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). BACKGROUND - Conventional right ventricular pacing causes electrical and mechanical left ventricular dys-synchrony and may worsen left ventricular systolic dysfunction and HF. Whether conventional pacing is also associate...
Original Research | By Khazanie P, Hellkamp AS, Hernandez AF et al.
BACKGROUND - Heart failure with preserved ejection fraction may be associated with chronotropic incompetence, but little is known about the incidence and prevalence of permanent pacemaker use in this population or factors associated with its use. METHODS - We analyzed patients with heart failure with preserved ejection fraction (ie, left ventricular ejection fraction greater than 40%) from the ADHERE ...
Review Article | By Burlacu A, Simion P, Nistor I et al.
Heart failure with preservedejectionfraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertional dyspnea being its clinical manifestation. The increasing pressure from LA is not based on volume overload...
Nitrosative stress drives heart failure with preserved ejection fraction
Original Research | By Schiattarella GG, Altamirano F, Hill JA et al.
Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with high morbidity and mortality for which there are no evidence-based therapies. Here we report that concomitant metabolic and hypertensive stress in mice-elicited by a combination of high-fat diet and inhibition of constitutive nitric oxide synthase using Nω-nitro-L-arginine methyl ester (L-NAME)-recapitulates the numerous systemic and cardi...
Original Research | By Komatsu Y, Hocini M, Nogami A et al.
BACKGROUND - Ventricular fibrillation (VF) storm after myocardial infarction (MI) is a life-threatening condition that necessitates multiple defibrillations. Catheter ablation is a potentially effective treatment strategy for VF storm refractory to optimal medical treatment. However, its impact on patient survival has not been verified in a large population. METHODS - We conducted a multicenter, retro...
Successful catheter ablation of electrical storm after myocardial infarction