Consensus | By Mintz GS, Lefèvre T, Lassen JF et al.
Interventional cardiology and coronary stent insertion have an increasing role in the optimal management of left main coronary artery (LMCA) stenosis. Assessing the extent of obstructive disease of the LMCA by angiography alone can be challenging. However, in contrast to the two-dimensional, shadow graphic nature of coronary angiography, intravascular ultrasound (IVUS) is an accurate tomographic technique for assessing both...
Consensus | By Ormiston JA, Kassab G, Finet G et al.
This is a consensus document from the European Bifurcation Club concerning bench testing in coronary artery bifurcations. It is intended to provide guidelines for bench assessment of stents and other strategies in coronary bifurcation treatment where the United States Food and Drug Administration (FDA) or International Organization for Standardization (ISO) guidelines are limited or absent. These recommendations provide guidelines rather t...
Consensus | By Lassen JF, Burzotta F, Banning AP et al.
The European Bifurcation Club (EBC) was initiated in 2004 to support a continuous overview of the field of coronary artery bifurcation interventions and aims to facilitate a scientific discussion and an exchange of ideas on the management of bifurcation disease. The EBC hosts an annual, two-day compact meeting, dedicated to bifurcations, which brings together physicians, pathologists, engineers, biologists, physicists, mathematicia...
Original Research | By Wehner GJ, Jing L, Haggerty CM et al.
AIMS - We investigated the relationship between clinically assessed left ventricular ejection fraction (LVEF) and survival in a large, heterogeneous clinical cohort. METHODS AND RESULTS - Physician-reported LVEF on 403 977 echocardiograms from 203 135 patients were linked to all-cause mortality using electronic health records (1998-2018) from US regional healthcare system. Cox proportional hazards ...
Original Research | By Räber L, Koskinas KC, Yamaji K et al.
OBJECTIVES - This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment. BACKGROUND - OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo...
When, where, and how to target vascular inflammation in the post-CANTOS era?
Editorial | By Maffia P, Guzik TJ.
This editorial refers to ‘Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis’, by A. Vrommanetal., doi:10.1093/eurheartj/ehz008
Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis
Original Research | By Vromman A, Ruvkun V, Shvartz E et al.
AIMS - Targeting interleukin-1 (IL-1) represents a novel therapeutic approach to atherosclerosis. CANTOS demonstrated the benefits of IL-1β neutralization in patients post-myocardial infarction with residual inflammatory risk. Yet, some mouse data have shown a prominent role of IL-1α rather than IL-1β in atherosclerosis, or even a deleterious effect of IL-1 on outward arterial remodelling in atherosclerosis-susceptible mice. T...
Systemic microvascular dysfunction in microvascular and vasospastic angina
Original Research | By Ford TJ, Rocchiccioli P, Good R et al.
The spectrum of chronic coronary syndromes: genetics, imaging, and management after PCI and CABG
Updated clinical classification of pulmonary hypertension
Review Article | By Simonneau G, Gatzoulis MA, Adatia I et al.