Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults
Original Research | By Miedema MD, Dardari ZA, Nasir K et al.
Review Article | By Ando T, Ashraf S, Villablanca P et al.
Transcatheter aortic valve implantation (TAVI) has been used to treat high surgical risk cohorts but has been expanded to treat low-to-intermediate risk cohort as well. We performed a systematic review and meta-analysis to compare the outcomes between TAVI and surgical aortic valve replacement (SAVR) in low-to-intermediate risk cohort. We queried PUBMED, EMBASE, and ClinicalTrial.gov for relevant articles. Randomized con...
Original Research | By Thourani VH, Suri RM, Gunter RL et al.
Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
Clinical Trial | By Popma JJ, Deeb GM, Evolut Low Risk Trial Investigators.
BACKGROUND - Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in patients with severe aortic stenosis who are at increased risk for death from surgery; less is known about TAVR in low-risk patients. METHODS - We performed a randomized noninferiority trial in which TAVR with a self-expanding supraannular bioprosthesis was compared with surgical aortic-valve replace...
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
Clinical Trial | By Mack MJ, Leon MB, PARTNER 3 Investigators.
BACKGROUND - Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence regarding the comparison of the two procedures in patients who are at low risk. METHODS - We randomly assigned patients with severe aorti...
Clinical Trial | By Nielsen HH1, Klaaborg KE, Nissen H et al.
AIMS - In a prospective randomised trial we aimed to compare transapical transcatheter aortic valve implantation (a-TAVI) with surgical aortic valve replacement (SAVR) in operable elderly patients. METHODS AND RESULTS - The study was designed as a randomised controlled trial of a-TAVI (Edwards SAPIEN heart valve system; Edwards Lifesciences, Irvine, CA, USA) vs. SAVR....
Transcatheter aortic-valve replacement with a self-expanding prosthesis
Clinical Trial | By Adams DH, Popma JJ, U.S. CoreValve Clinical Investigators.
BACKGROUND - We compared transcatheter aortic-valve replacement (TAVR), using a self-expanding transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in patients with severe aortic stenosis and an increased risk of death during surgery. METHODS - We recruited patients with severe aortic stenosis who were at increased surgical risk as determined by the heart team at each stud...
Clinical Trial | By Thyregod HG, Steinbrüchel DA, Ihlemann N et al.
Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients
Clinical Trial | By Leon MB, Smith CR, PARTNER 2 Investigators.
BACKGROUND - Previous trials have shown that among high-risk patients with aortic stenosis, survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. We evaluated the two procedures in a randomized trial involving intermediate-risk patients. METHODS - We randomly assigned 2032 intermediate-risk patients with severe aortic stenosis, at 57 centers, to und...